B细胞祖细胞在免疫球蛋白重链定向前后具有不同的生长需求。
B cell progenitors have different growth requirements before and after immunoglobulin heavy chain commitment.
作者信息
Sauter H, Paige C J
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
J Exp Med. 1988 Oct 1;168(4):1511-6. doi: 10.1084/jem.168.4.1511.
Using the clonable pre-B cell assay, we have identified B cell progenitors that are not yet committed to the production of a particular H chain allele. These cells represent approximately 10-20% of clonable pre-B cells found in 15-d fetal liver. The clonable pre-B cell assay provides an environment adequate for the expansion and differentiation of these cells into mature, Ig-secreting, cells. Using the same methodology, we have also identified progenitors that are uncommitted to the production of a particular L chain isotype. Moreover, investigating the growth requirements for clonable pre-B cells has led to the discovery of selective growth conditions that distinguish cells before and after commitment to H chain allotype.
利用可克隆前B细胞检测法，我们鉴定出了尚未定向产生特定重链等位基因的B细胞祖细胞。这些细胞约占15日龄胎肝中可克隆前B细胞的10%-20%。可克隆前B细胞检测法提供了一个足以使这些细胞扩增并分化为成熟的、分泌免疫球蛋白的细胞的环境。使用相同的方法，我们还鉴定出了尚未定向产生特定轻链同种型的祖细胞。此外，对可克隆前B细胞生长需求的研究已导致发现了能区分重链同种异型定向前后细胞的选择性生长条件。
Zotero 插件