Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
Department of Clinic medicine, School of Queen Mary, Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
Reprod Biol Endocrinol. 2019 Aug 9;17(1):65. doi: 10.1186/s12958-019-0511-x.
Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.
Kisspeptin 及其 G 蛋白偶联受体 KISS1R 在哺乳动物生殖中发挥着关键作用，因为它们参与了青春期的开始和下丘脑-垂体-性腺轴的控制。然而，最近的研究表明 kisspeptin 在生殖功能中可能具有潜在的作用。在这里，我们总结了我们对 kisspeptin/KISS1R 在周围生殖系统（包括卵巢、睾丸、子宫和胎盘）中的生理意义的理解的最新进展，以及 kisspeptin/KISS1R 在生殖疾病中的潜在作用。全面了解 kisspeptin/KISS1R 在周围生殖系统中的表达、功能和潜在分子机制，将有助于生殖疾病的诊断、治疗和预防。
