测量近视儿童不同调节状态下的 Schlemm 管和小梁网的变化：一项观察性研究。

Measuring changes in Schlemm's canal and trabecular meshwork in different accommodation states in myopia children: an observational study.

机构信息

Department of Ophthalmology, Tongji hospital, Tongji medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China.

School of Human and Social Sciences, University of West London, London, UK.

出版信息

Eye (Lond). 2020 Feb;34(2):374-382. doi: 10.1038/s41433-019-0548-2. Epub 2019 Aug 9.

DOI:10.1038/s41433-019-0548-2

PMID:31399701

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7002585/

Abstract

PURPOSE

The aim of the study was to evaluate changes in size of Schlemm's canal (SC) and trabecular meshwork(TM) in response to accommodation stimuli and cycloplegia states in myopia children.

METHODS

In total, 34 children were enroled in this study. A -6.0 D accommodation stimulus was achieved by looking at an optotype through a mirror. Cycloplegia state was induced with 1% tropicamide. Two states were confirmed by measuring the central lens thickness (CLT), anterior chamber depth and pupil diameter. The size of SC and TM was measured using swept-source optical coherence tomography. The association between changes in SC size and CLT was analysed.

RESULTS

Compared with that in the relaxation state, SC size increased significantly under -6.0 D accommodation stimuli. SC area (SCA) increased from 6371 ± 2517 μm to 7824 ± 2727 μm, SC length (SCL) from 249 ± 10 μm to 295 ± 12 μm and SC width (SCW) from 27 ± 9 μm to 31 ± 8 μm. Under the cycloplegia state, SCA decreased to 5009 ± 2028 μm; SCL to 212 ± 14 μm, and SCW to 22 ± 5 μm. Changes in SCA (r = 0.35, P = 0.0007), SCL (r = 0.251, P = 0.0172) and SCW (r = 0.253, P = 0.016) were significantly correlated with changes in CLT. TM size was not significantly altered compared to that in the relaxation state. TM length (TML) increased from 562 ± 45 μm to 587 ± 47 μm after exposure to -6.0 D accommodation stimulus.

CONCLUSION

SC size enlarged in response to -6.0 D accommodation stimuli and shrunk under cycloplegia. TM length increased under the accommodation stimulus state.

摘要

目的

本研究旨在评估近视儿童在调节刺激和睫状肌麻痹状态下 Schlemm 管（SC）和小梁网（TM）大小的变化。

方法

共纳入 34 名儿童。通过在镜子中观察视标来实现-6.0 D 的调节刺激。用 1%托吡卡胺诱导睫状肌麻痹状态。通过测量中央晶状体厚度（CLT）、前房深度和瞳孔直径来确认两种状态。使用扫频源光学相干断层扫描测量 SC 和 TM 的大小。分析 SC 大小变化与 CLT 之间的关系。

结果

与松弛状态相比，在-6.0 D 调节刺激下，SC 大小显著增大。SC 面积（SCA）从 6371±2517μm 增加到 7824±2727μm，SC 长度（SCL）从 249±10μm 增加到 295±12μm，SC 宽度（SCW）从 27±9μm 增加到 31±8μm。在睫状肌麻痹状态下，SCA 减少到 5009±2028μm；SCL 为 212±14μm，SCW 为 22±5μm。SCA 的变化（r=0.35，P=0.0007）、SCL 的变化（r=0.251，P=0.0172）和 SCW 的变化（r=0.253，P=0.016）与 CLT 的变化显著相关。与松弛状态相比，TM 大小无明显变化。在暴露于-6.0 D 调节刺激后，TM 长度从 562±45μm 增加到 587±47μm。