Department of Gynecology & Obstetrics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Biol Trace Elem Res. 2020 May;195(1):46-54. doi: 10.1007/s12011-019-01844-x. Epub 2019 Aug 10.
The aim of the present study was to evaluate serum concentrations of copper (Cu) and zinc (Zn), in relation with metabolic profile and clinicopathologic features of patients with endometrial cancer. A total of 47 women with endometrial cancer and 45 controls were eligible for the study. Clinicopathologic features and metabolic profile as well as serum copper and zinc levels were evaluated in each subject. Patients with endometrial cancer (Cu mean 3.72 ± 2.15 mg/L, median 3.54 [0.41-9.16] mg/L and Zn mean 1.83 ± 0.71 mg/L, median 1.77 [0.71-4.02] mg/L) exhibited lower Cu and Zn levels than those of controls (Cu mean 6.06 ± 1.79 mg/L, median 6.32 [2.95-9.05] mg/L and Zn mean 2.48 ± 0.89 mg/L, median 2.23 [1.23-4.54] mg/L) (p < 0.001). Cu/Zn ratio was also higher (0.85 ± 1.96 vs. 2.57 ± 0.73) in controls as compared with patients with endometrial cancer. While Cu levels showed no significant correlation with age, body mass index, gravidity, and parity, a positive correlation was found between Zn levels and parity. When cancer patients were evaluated on their own, both Cu and Zn levels showed positive correlation with age. Additionally, the cancer patients with myometrial invasion > 1/2 exhibited lower Cu levels compared with the cancer patients with myometrial invasion < 1/2. The data of the present study suggested that women with endometrial cancer are characterized by altered serum Cu and Zn levels as compared with controls. Imbalance of these trace element levels might be associated with endometrial cancer among Turkish patients.
本研究旨在评估血清铜（Cu）和锌（Zn）浓度与子宫内膜癌患者的代谢特征和临床病理特征的关系。共有 47 名子宫内膜癌患者和 45 名对照者符合研究条件。对每位患者进行临床病理特征、代谢特征以及血清铜和锌水平的评估。与对照组（Cu 平均 3.72±2.15mg/L，中位数 3.54[0.41-9.16]mg/L；Zn 平均 1.83±0.71mg/L，中位数 1.77[0.71-4.02]mg/L）相比，子宫内膜癌患者（Cu 平均 6.06±1.79mg/L，中位数 6.32[2.95-9.05]mg/L；Zn 平均 2.48±0.89mg/L，中位数 2.23[1.23-4.54]mg/L）的血清 Cu 和 Zn 水平较低（p<0.001）。与对照组相比，患者的 Cu/Zn 比值（0.85±1.96）也更高。Cu 水平与年龄、体重指数、孕次和产次无显著相关性，而 Zn 水平与产次呈正相关。当单独评估癌症患者时，Cu 和 Zn 水平与年龄呈正相关。此外，与肌层浸润<1/2 的癌症患者相比，肌层浸润>1/2 的癌症患者的 Cu 水平较低。本研究数据表明，与对照组相比，子宫内膜癌患者的血清 Cu 和 Zn 水平发生改变。这些微量元素水平的失衡可能与土耳其患者的子宫内膜癌有关。
