Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, 30912, USA.
Adv Exp Med Biol. 2019;1165:557-584. doi: 10.1007/978-981-13-8871-2_28.
Renal fibrosis is the final common pathway of all chronic kidney diseases progressing to end-stage renal diseases. Autophagy, a highly conserved lysosomal degradation pathway, plays important roles in maintaining cellular homeostasis in all major types of kidney cells including renal tubular cells as well as podocytes, mesangial cells and endothelial cells in glomeruli. Autophagy dysfunction is implicated in the pathogenesis of various renal pathologies. Here, we analyze the pathological role and regulation of autophagy in renal fibrosis and related kidney diseases in both glomeruli and tubulointerstitial compartments. Further research is expected to gain significant mechanistic insights and discover pathway-specific and kidney-selective therapies targeting autophagy to prevent renal fibrosis and related kidney diseases.
肾纤维化是所有进展为终末期肾病的慢性肾脏病的共同终末途径。自噬是一种高度保守的溶酶体降解途径，在包括肾小管细胞以及肾小球中的足细胞、系膜细胞和内皮细胞在内的所有主要类型的肾细胞中，对于维持细胞内稳态发挥着重要作用。自噬功能障碍与各种肾脏病理的发病机制有关。在这里，我们分析了自噬在肾小球和肾小管间质区的肾纤维化和相关肾脏疾病中的病理作用和调节。进一步的研究有望获得显著的机制见解，并发现针对自噬的具有通路特异性和肾脏选择性的治疗方法，以预防肾纤维化和相关肾脏疾病。
