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岩藻黄质通过调节氧化应激过程、炎症反应及模型来减轻肾脏衰老。

Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response and models.

作者信息

Zhang Xiaomei, Qiang Weidong, Guo Yongxin, Gong Jingli, Yu Huan, Wu Di, Tang Pengxiang, Yidan Ma, Zhang Huifeng, Sun Xin

机构信息

School of Pharmacy, Jilin Medical University, Jilin, People's Republic of China.

College of Medicine, Huanghuai University, Zhumadian, People's Republic of China.

出版信息

Redox Rep. 2025 Dec;30(1):2511458. doi: 10.1080/13510002.2025.2511458. Epub 2025 Jun 9.

DOI:10.1080/13510002.2025.2511458
PMID:40489575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12150648/
Abstract

OBJECTIVES

Many countries in the world are entering society with an aging population. The kidney is one of the most sensitive organs in the body to aging. Kidney function gradually declines with aging. Renal aging is one of the main triggers of CDK. Therefore, many researchers in the field are looking for natural, green and healthy anti-renal-aging bioactive molecules.

METHODS AND RESULTS

Western-blot, ELISA and indirect immunofluorescence were performed to evaluate the biological activity of fucoxanthin against renal aging and models. First, in the model, we evaluated the effect of fucoxanthin on renal cell senescence. We found that fucoxanthin could alleviate the kidney cell senescence caused by HO by detecting a series of senescence markers. In the model, the experimental results showed that fucoxanthin could alleviate the aging of the kidney by Sa-β-gal staining and detection of aging-related marker molecules. Furthermore, we also found that fucoxanthin could alleviate kidney fibrosis.

CONCLUSIONS

In this study, our results showed that fucoxanthin was able to alleviate renal aging and models, suggesting that fucoxanthin could be a functional food to treat and relieve kidney aging.

摘要

目的

世界上许多国家正在步入人口老龄化社会。肾脏是人体中对衰老最为敏感的器官之一。肾功能会随着衰老而逐渐衰退。肾脏老化是慢性肾脏病（CDK）的主要诱因之一。因此，该领域的许多研究人员都在寻找天然、绿色且健康的抗肾脏衰老生物活性分子。

方法与结果

采用蛋白质免疫印迹法（Western-blot）、酶联免疫吸附测定法（ELISA）和间接免疫荧光法来评估岩藻黄质对肾脏衰老及相关模型的生物活性。首先，在该模型中，我们评估了岩藻黄质对肾细胞衰老的影响。通过检测一系列衰老标志物，我们发现岩藻黄质能够减轻由过氧化氢（HO）引起的肾细胞衰老。在另一模型中，实验结果表明，通过衰老相关β-半乳糖苷酶（Sa-β-gal）染色和检测衰老相关标志物分子，岩藻黄质能够减轻肾脏的老化。此外，我们还发现岩藻黄质可以减轻肾纤维化。

结论

在本研究中，我们的结果表明岩藻黄质能够减轻肾脏衰老及相关模型中的症状，这表明岩藻黄质可能是一种用于治疗和缓解肾脏衰老的功能性食品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/539fe6327fe3/YRER_A_2511458_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/5f7b70e52e1a/YRER_A_2511458_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/27a864faadc1/YRER_A_2511458_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/914fe36d829d/YRER_A_2511458_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/f4532e57ba8a/YRER_A_2511458_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/ed3ead733bc5/YRER_A_2511458_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/c375038e4da3/YRER_A_2511458_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/e86e2898f831/YRER_A_2511458_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/539fe6327fe3/YRER_A_2511458_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/5f7b70e52e1a/YRER_A_2511458_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/27a864faadc1/YRER_A_2511458_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/914fe36d829d/YRER_A_2511458_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/f4532e57ba8a/YRER_A_2511458_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/ed3ead733bc5/YRER_A_2511458_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/c375038e4da3/YRER_A_2511458_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/e86e2898f831/YRER_A_2511458_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149f/12150648/539fe6327fe3/YRER_A_2511458_F0008_OC.jpg

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Front Pharmacol. 2022 Aug 2;13:929442. doi: 10.3389/fphar.2022.929442. eCollection 2022.
2
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Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12.
3
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Eur J Pharmacol. 2021 Dec 15;913:174629. doi: 10.1016/j.ejphar.2021.174629. Epub 2021 Nov 12.
4
Host and microbiota metabolic signals in aging and longevity.宿主和微生物群的代谢信号与衰老和长寿。
Nat Chem Biol. 2021 Oct;17(10):1027-1036. doi: 10.1038/s41589-021-00837-z. Epub 2021 Sep 22.
5
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Nat Immunol. 2021 Jun;22(6):687-698. doi: 10.1038/s41590-021-00927-z. Epub 2021 May 13.
6
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7
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8
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