An Dong-Yang, Tan Jun, Lu Yan-Dan, Wen Ze-Huai, Bao Yi-Ni, Yao Zhou-Hui, Chen Zi-Yan, Wang Ping-Ping, Zhou Wei, Yang Qiao, Hao Min
School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.
Front Pharmacol. 2024 Nov 15;15:1454586. doi: 10.3389/fphar.2024.1454586. eCollection 2024.
Diabetic kidney disease (DKD) is a common pathway to End-stage renal disease (ESRD). Podocytes are crucial due to their dual barrier functions in kidney diseases. Their role in renal fibrosis and DKD regulatory mechanisms is increasingly studied. However, bibliometric research in this field has not been explored.
1,250 publications from Jan. 1, 2000, to Feb. 16, 2024, were retrieved from the WoSCC database and analyzed by the Web of Science results analysis tool, VOSviewer, and CiteSpace.
Our scrutiny reveals that authors Liu Youhua, Fogo Agnes B, and Zhao Yingyong have made substantial contributions to this domain. Notably, "Kidney International" has the highest volume of publications in this area. Furthermore, our analysis identifies ten co-citation clusters: DKD, IncRNA, reactive oxygen species, glomerulosclerosis, Poria cocos, glomerular diseases, fibroblasts, connective tissue growth factor, coagulation, and Wnt. Recent research accentuates keywords such as autophagy, TRPC6, ERS, epigenetics, and NLRP3 inflammasome as frequently occurring terms in this field. The prevailing research hotspot keywords include autophagy, biomarker, and exosomes.
Through the utilization of bibliometric tools and knowledge graph analysis, we have undertaken a comprehensive review of the intricate nexus between podocytes in DKD and renal fibrosis. This study imparts valuable insights to scholars regarding the dynamic evolution of this association and delineates prospective research avenues in this pivotal realm.
糖尿病肾病（DKD）是终末期肾病（ESRD）的常见途径。足细胞因其在肾脏疾病中的双重屏障功能而至关重要。它们在肾纤维化和DKD调节机制中的作用得到了越来越多的研究。然而，该领域的文献计量学研究尚未开展。
从WoSCC数据库中检索了2000年1月1日至2024年2月16日的1250篇出版物，并通过Web of Science结果分析工具、VOSviewer和CiteSpace进行分析。
我们的审查发现，刘友华、福戈·阿格尼斯·B和赵英勇等作者对该领域做出了重大贡献。值得注意的是，《国际肾脏病杂志》在该领域的出版物数量最多。此外，我们的分析确定了十个共被引聚类：DKD、IncRNA、活性氧、肾小球硬化、茯苓、肾小球疾病、成纤维细胞、结缔组织生长因子、凝血和Wnt。近期研究强调自噬、瞬时受体电位通道蛋白6（TRPC6）、内质网应激（ERS）、表观遗传学和NLRP3炎性小体等关键词是该领域经常出现的术语。当前的研究热点关键词包括自噬、生物标志物和外泌体。
通过利用文献计量工具和知识图谱分析，我们对DKD中足细胞与肾纤维化之间的复杂联系进行了全面综述。本研究为学者们提供了关于这种关联动态演变的宝贵见解，并勾勒了这一关键领域的前瞻性研究途径。
