Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Adv Exp Med Biol. 2019;1165:693-709. doi: 10.1007/978-981-13-8871-2_34.
Extracellular vesicles (EVs) are small lipid-based membrane-bound vesicles secreted by most cells under both physiological and pathological conditions. A key function of EVs is to mediate cell-cell communication via transferring mRNAs, miRNAs and proteins from parent cells to recipient cells. These unique features of EVs have spurred a renewed interest in their utility for therapeutics. Given the growing evidence for EV-mediated renal diseases, strategies that could block the release or uptake of pathogenic EVs will be discussed in this review. Then, the therapeutic potential of EVs predominantly from stem cells in renal diseases will be outlined. Finally, we will focus on the specific application of EVs as a novel drug delivery system and highlight the challenges of EVs-based therapies for renal diseases.
细胞外囊泡 (EVs) 是在生理和病理条件下大多数细胞分泌的小型基于脂质的膜结合囊泡。EVs 的一个关键功能是通过将 mRNA、miRNA 和蛋白质从亲代细胞传递到受体细胞来介导细胞间通讯。EVs 的这些独特特性激发了人们对其在治疗中的应用的重新关注。鉴于越来越多的证据表明 EV 介导的肾脏疾病，本综述将讨论能够阻断致病 EV 释放或摄取的策略。然后，将概述主要来自干细胞的 EV 在肾脏疾病中的治疗潜力。最后，我们将重点讨论 EV 作为新型药物递送系统的具体应用，并强调 EV 治疗肾脏疾病的挑战。
