Lopantsev V E, Taranenko V D
Neirofiziologiia. 1988;20(3):357-65.
The peculiarities of the activity of cortical isolated slab neurons were investigated in experiments on unanaesthetized and immobilized cats during the development of seizure spikes evoked by repetitive powerful stimulation. It was shown that in the investigated focus of epileptiform discharges the neurons were not differentiated by the degree of pathological alterations, since paroxysmal membrane potential shifts of all neurons were recorded intracellularly. All these neurons were characterized by a lack of the spike activity. At the same time bursting spike discharges of isolated slab neurons were recorded extracellularly and they did not propagate to the soma. Simultaneous extra- and intracellular recordings of the activity from the same neurons have shown that during the epileptiform activity action potentials were generated in some trigger zones without propagating to the cell bodies. Possible mechanisms of the origin of the spike activity in isolated slab neurons during the development of generalized epileptiform state are discussed.
在对未麻醉且固定的猫进行的实验中，研究了重复强刺激诱发癫痫发作尖峰期间皮质孤立板层神经元活动的特点。结果表明，在癫痫样放电的研究病灶中，神经元并未因病理改变程度而有所区分，因为在细胞内记录到所有神经元的阵发性膜电位变化。所有这些神经元的特征是缺乏锋电位活动。与此同时，在细胞外记录到了孤立板层神经元的爆发性锋电位放电，且它们并未传播至胞体。对同一神经元活动的细胞外和细胞内同步记录表明，在癫痫样活动期间，动作电位在一些触发区产生，但并未传播至细胞体。文中讨论了全身性癫痫样状态发展过程中孤立板层神经元锋电位活动产生的可能机制。
