Asahina Kenta, Zelikowsky Moriel
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Department of Neurobiology, School of Medicine, The University of Utah, Salt Lake City, Utah.
Biol Psychiatry. 2025 May 15;97(10):942-952. doi: 10.1016/j.biopsych.2025.01.019. Epub 2025 Jan 30.
Chronic social isolation alters behavior across animal species. Genetic model organisms such as mice and flies provide crucial insight into the molecular and physiological effects of social isolation on brain cells and circuits. Here, we comparatively review recent findings regarding the function of conserved neuropeptides in social isolation in mice and flies. Analogous functions of 3 classes of neuropeptides-tachykinins, cholecystokinins, and neuropeptide Y/F-in the two model organisms suggest that these molecules may be involved in modulating behavioral changes induced by social isolation across a wider range of species, including humans. Comparative approaches armed with tools to dissect neuropeptidergic function can lead to an integrated understanding of the impacts of social isolation on brain circuits and behavior.
长期社会隔离会改变不同动物物种的行为。小鼠和果蝇等基因模式生物为深入了解社会隔离对脑细胞和神经回路的分子及生理影响提供了关键见解。在此，我们比较性地综述了近期关于保守神经肽在小鼠和果蝇社会隔离中的功能的研究结果。两类模式生物中速激肽、胆囊收缩素和神经肽Y/F这三类神经肽的类似功能表明，这些分子可能参与调节包括人类在内的更广泛物种因社会隔离引起的行为变化。配备剖析神经肽能功能工具的比较方法能够使人们对社会隔离对神经回路和行为的影响有综合的理解。
