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2005 - 2016年美国糖尿病照护级联评估

Evaluation of the Cascade of Diabetes Care in the United States, 2005-2016.

作者信息

Kazemian Pooyan, Shebl Fatma M, McCann Nicole, Walensky Rochelle P, Wexler Deborah J

机构信息

Medical Practice Evaluation Center, Massachusetts General Hospital, Boston.

Division of General Internal Medicine, Massachusetts General Hospital, Boston.

出版信息

JAMA Intern Med. 2019 Oct 1;179(10):1376-1385. doi: 10.1001/jamainternmed.2019.2396.

Abstract

IMPORTANCE

Treatment advances in diabetes can meaningfully improve outcomes only if they effectively reach the populations at risk.

OBJECTIVES

To evaluate whether the cascade of US diabetes care, defined as diabetes diagnosis, linkage to care, and achievement of individual and combined treatment targets, improved from 2005 to 2016 and to investigate potential disparities in US diabetes care.

DESIGN, SETTING, AND PARTICIPANTS: Nationally representative, serial cross-sectional studies included in the 2005-2016 National Health and Nutrition Examination Survey were evaluated. Data on nonpregnant US adults (age ≥18 years) with diabetes who had reported fasting for 9 or more hours (n = 1742 diagnosed and 746 undiagnosed) were included. Data analysis was performed from August 1, 2018, to May 10, 2019.

EXPOSURES

Time period (2005-2008, 2009-2012, and 2013-2016), age, sex, race/ethnicity, health insurance, and educational level incorporated into logistic regression models predicting odds of target achievement.

MAIN OUTCOMES AND MEASURES

Proportion of participants overall and stratified by age, sex, and race/ethnicity who were linked to diabetes care and met glycemic (hemoglobin A1c <7.0%-8.5%, depending on age and complications), blood pressure (<140/90 mm Hg), cholesterol level (low-density lipoprotein cholesterol <100 mg/dL), and smoking abstinence targets and a composite of all targets.

RESULTS

In 2013-2016, of 1742 US adults with diagnosed diabetes, 94% (95% CI, 92%-96%) were linked to diabetes care; 64% (95% CI, 58%-69%) met hemoglobin A1c level, 70% (95% CI, 64%-75%) met blood pressure level, and 57% (95% CI, 51%-62%) met cholesterol level targets; 85% were nonsmokers (95% CI, 82%-88%); and 23% (95% CI, 17%-29%) achieved the composite goal. Results were similar in 2005-2008 (composite 23%) and in 2009-2012 (composite 25%). There was no significant improvement in diagnosis or target achievement during the study period. Compared with middle-aged adults (45-64 years) with diagnosed diabetes, older patients (≥65 years) had higher odds (adjusted odds ratio [aOR], 1.70; 95% CI, 1.17-2.48) and younger adults (18-44 years) had lower odds (aOR, 0.53; 95% CI, 0.29-0.97) of meeting the composite target. Women had lower odds of achieving the composite target than men (aOR, 0.60; 95% CI, 0.45-0.80). Non-Hispanic black individuals vs non-Hispanic white individuals had lower odds of achieving the composite target (aOR, 0.57; 95% CI, 0.39-0.83). Having health insurance was the strongest predictor of linkage to diabetes care (aOR, 3.96; 95% CI, 2.34-6.69).

CONCLUSIONS AND RELEVANCE

It appears that the diabetes care cascade in the United States has not significantly improved between 2005 and 2016. This study's findings suggest that gaps in diabetes care that were present in 2005, particularly among younger adults (18-44 years), women, and nonwhite individuals, persist.

摘要

重要性

糖尿病治疗的进展只有在有效惠及高危人群时,才能切实改善治疗效果。

目的

评估2005年至2016年期间美国糖尿病照护的级联情况(定义为糖尿病诊断、与照护的关联以及个体和综合治疗目标的达成)是否有所改善,并调查美国糖尿病照护中潜在的差异。

设计、背景和参与者:对纳入2005 - 2016年国家健康与营养检查调查的具有全国代表性的系列横断面研究进行评估。纳入了报告禁食9小时或更长时间的美国成年糖尿病患者(年龄≥18岁)的数据(n = 1742例已诊断和746例未诊断)。数据分析于2018年8月1日至2019年5月10日进行。

暴露因素

时间段(2005 - 2008年、2009 - 2012年和2013 - 2016年)、年龄、性别、种族/民族、医疗保险和教育水平纳入逻辑回归模型,以预测目标达成的几率。

主要结局和指标

总体参与者以及按年龄、性别和种族/民族分层的参与者中,与糖尿病照护相关联且达到血糖(糖化血红蛋白<7.0% - 8.5%,取决于年龄和并发症)、血压(<140/90 mmHg)、胆固醇水平(低密度脂蛋白胆固醇<100 mg/dL)和戒烟目标以及所有目标综合指标的比例。

结果

在2013 - 2016年期间,1742例已诊断糖尿病的美国成年人中,94%(95%CI,92% - 96%)与糖尿病照护相关联;64%(95%CI,58% - 69%)达到糖化血红蛋白水平,70%(95%CI,64% - 75%)达到血压水平,57%(95%CI,51% - 62%)达到胆固醇水平目标;85%为非吸烟者(95%CI,82% - 88%);23%(95%CI,17% - 29%)实现了综合目标。2005 - 2008年(综合目标达成率23%)和2009 - 2012年(综合目标达成率25%)的结果相似。研究期间,诊断或目标达成情况没有显著改善。与已诊断糖尿病的中年成年人(45 - 64岁)相比,老年患者(≥65岁)达到综合目标的几率更高(调整优势比[aOR],1.70;95%CI,1.17 - 2.48),而年轻成年人(18 - 44岁)达到综合目标的几率更低(aOR,0.53;95%CI,0.29 - 0.97)。女性达到综合目标的几率低于男性(aOR,0.60;95%CI,0.45 - 0.80)。非西班牙裔黑人个体与非西班牙裔白人个体相比,达到综合目标的几率更低(aOR,0.57;95%CI,0.39 - 0.83)。拥有医疗保险是与糖尿病照护相关联的最强预测因素(aOR,3.96;95%CI,2.34 - 6.69)。

结论与意义

2005年至2016年期间,美国糖尿病照护的级联情况似乎没有显著改善。本研究结果表明,2005年存在的糖尿病照护差距,尤其是在年轻成年人(18 - 44岁)、女性和非白人个体中,仍然存在。

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