VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Lab Protein Chemistry, Proteomics & Epigenetic Signalling (PPES), Department Biomedical Sciences, University of Antwerp, Wilrijk, Belgium.
Biochem Pharmacol. 2020 Mar;173:113602. doi: 10.1016/j.bcp.2019.08.004. Epub 2019 Aug 9.
Despite the recent successes of targeted cancer immuno-therapies, drug resistance and disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed interest in natural product discovery to identify new pharmacophores for innovative cancer drug development. Reverse pharmacology approaches of Withania somnifera leaves and roots (alternatively also called Ashwagandha or Indian ginseng in traditional Ayurvedic and Unani folk medicine) have identified Withaferin A (WA) as the most bioactive compound for treatment of inflammatory ailments, supporting traditional use of their corresponding extracts in indigenous medicine. In this review we summarize preclinical in vivo evidence for therapeutic cancer applications of WA and provide a biochemical framework of its polypharmaceutical effects against cancer hallmarks.
尽管最近靶向癌症免疫疗法取得了成功，但耐药性和疾病复发仍然是癌症患者治疗的巨大负担。这激发了人们对天然产物发现的新兴趣，以寻找新的药效团，用于创新的癌症药物开发。对睡茄叶和根（在传统的阿育吠陀和顺势疗法民间医学中也被称为 Ashwagandha 或印度人参）的反向药理学方法已经确定 Withaferin A（WA）是治疗炎症疾病最有效的化合物，这支持了其相应提取物在本土医学中的传统用途。在这篇综述中，我们总结了 WA 治疗癌症应用的临床前体内证据，并提供了其对抗癌症标志的多药作用的生化框架。
