从细叶假万寿竹的叶子中分离和结构鉴定环肽生物碱。

Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia.

机构信息

Laboratoire de Chimie Organique Biologique, UFR Sciences des Structures de La Matière et Technologie, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan 22, Cote d'Ivoire; ICMR-UMR CNRS 7312, Equipe Chimie des Substances Naturelles, Campus Sciences, Bât. 18, BP 1039, 51687, Reims, France.

ICMR-UMR CNRS 7312, Equipe Chimie des Substances Naturelles, Campus Sciences, Bât. 18, BP 1039, 51687, Reims, France.

出版信息

Phytochemistry. 2019 Nov;167:112081. doi: 10.1016/j.phytochem.2019.112081. Epub 2019 Aug 9.

DOI:10.1016/j.phytochem.2019.112081

PMID:31404786

Abstract

Heisteria parvifolia Sm. is prescribed in traditional medecine against numerous diseases in Côte d'Ivoire. Due to the shortcoming in scientifical knowledge of use of this species, our investigations revealed five undescribed cyclopeptide alkaloids added to one known derivative namely anorldianine. These compounds were elucidated by 1D and 2D-NMR experiments and comparison with literature data, and confirmed by HR-ESI-MS. Cytotoxic activity evaluation of these compounds against the chronic myeloid leukemia (K565) cell line exhibited an antiproliferative activity with cell growth inhibition from 13% to 46%.

摘要

Heisteria parvifolia Sm. 在科特迪瓦传统医学中被用于治疗许多疾病。由于对该物种使用的科学知识的不足，我们的研究发现了五种未被描述的环肽生物碱，加上一种已知的衍生物即 anorldianine。这些化合物通过 1D 和 2D-NMR 实验和与文献数据的比较进行阐明，并通过 HR-ESI-MS 得到证实。这些化合物对慢性髓性白血病（K565）细胞系的细胞毒性活性评估显示出抗增殖活性，细胞生长抑制率从 13%到 46%不等。