Abe T, Masuda T, Satodate R
Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan.
Virchows Arch A Pathol Anat Histopathol. 1988;413(5):457-62. doi: 10.1007/BF00716994.
Carbonized polyethylene microspheres of 3.53 micron diameter were injected intravenously into splenectomized, laparotomized, and untreated rats. The number of Kupffer cells which phagocytosed microspheres and the number of microspheres phagocytosed by single Kupffer cells were counted. The number of Kupffer cells which phagocytosed microspheres was 1.51 times greater in splenectomized rats than in untreated rats, and 1.29 times greater in splenectomized rats than in laparotomized rats, both values being statistically significant. Although this same value was 1.18 times greater in laparotomized rats than in untreated rats, this was not statistically significant. The number of microspheres phagocytosed by single Kupffer cells also increased significantly in splenectomized rats. The intra-acinar distribution of the phagocytosing Kupffer cells showed the number in the periportal area to be 8-9 times greater than in the central area in all 3 groups. No significant difference in this intra-acinar distribution was observed between the groups. In addition, there was no difference in the phagocytic activity of Kupffer cells and the distribution of phagocytosing Kupffer cells between the hepatic lobes.
将直径为3.53微米的碳化聚乙烯微球静脉注射到脾切除、开腹和未处理的大鼠体内。对吞噬微球的枯否细胞数量以及单个枯否细胞吞噬的微球数量进行计数。脾切除大鼠中吞噬微球的枯否细胞数量比未处理大鼠多1.51倍，比开腹大鼠多1.29倍，这两个数值均具有统计学意义。虽然开腹大鼠中的这一数值比未处理大鼠多1.18倍，但无统计学意义。脾切除大鼠中单个枯否细胞吞噬的微球数量也显著增加。吞噬微球的枯否细胞在腺泡内的分布显示，在所有3组中，门静脉周围区域的细胞数量比中央区域多8 - 9倍。各组之间在这种腺泡内分布上未观察到显著差异。此外，肝叶之间枯否细胞的吞噬活性以及吞噬微球的枯否细胞的分布没有差异。
