Zhang Boru, Wang Chenxi, Yang Wei, Zhang Hongyun, Meng Qingwei, Shi Baoming, Shan Anshan
Institute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030 People's Republic of China.
J Anim Sci Biotechnol. 2019 Aug 7;10:62. doi: 10.1186/s40104-019-0369-y. eCollection 2019.
Pyrroloquinoline quinone (PQQ), which is a water soluble, thermo-stable triglyceride-quinone, is widely distributed in nature and characterized as a mammalian vitamin-like redox cofactor. The objective of this study was to investigate the effects of pyrroloquinoline quinone disodium (PQQ·Na) on reproductive performance in sows.
Dietary supplementation with PQQ·Na significantly increased the total number of piglets born, the number of piglets born alive and the born alive litter weight. It also increased the antioxidant status in the placenta, plasma and milk. The concentration of NO was significantly increased in the plasma and placenta. RNA-seq analysis showed that 462 unigenes were differentially expressed between the control (Con) treatment and PQQ treatment groups. Among these unigenes, 199 were upregulated, while 263 unigenes were downregulated. The assigned functions of the unigenes covered a broad range of GO categories. Reproduction (27, 7.03%) and the reproduction process (27, 7.03%) were assigned to the biological process category. By matching DEGs to the KEGG database, we identified 29 pathways.
In conclusion, dietary supplementation with PQQ·Na in gestating and lactating sows had positive effects on their reproductive performance.
吡咯喹啉醌（PQQ）是一种水溶性、热稳定的甘油三酯醌，广泛分布于自然界，被表征为一种哺乳动物维生素样氧化还原辅助因子。本研究的目的是调查吡咯喹啉醌二钠（PQQ·Na）对母猪繁殖性能的影响。
日粮中添加PQQ·Na显著增加了产仔总数、活产仔数和活产窝重。它还提高了胎盘、血浆和乳汁中的抗氧化状态。血浆和胎盘中NO的浓度显著增加。RNA测序分析表明，对照（Con）处理组和PQQ处理组之间有462个单基因差异表达。在这些单基因中，199个上调，263个下调。单基因的指定功能涵盖了广泛的基因本体论（GO）类别。生殖（27个，7.03%）和生殖过程（27个，7.03%）被归入生物过程类别。通过将差异表达基因（DEG）与京都基因与基因组百科全书（KEGG）数据库进行比对，我们鉴定出29条途径。
总之，在妊娠和泌乳母猪日粮中添加PQQ·Na对其繁殖性能有积极影响。
