突变与大白猪和杜洛克猪的窝产仔数性状有关。
mutations are associated with litter size traits in Large White and Chinese DIV pigs.
机构信息
a Key Laboratory of Pig Genetics and Breeding of Ministry of Agriculture and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education , Huazhong Agricultural University , Wuhan , PR China.
b The Cooperative Innovation Center for Sustainable Pig Production , Wuhan , PR China.
出版信息
Anim Biotechnol. 2019 Jul;30(3):212-218. doi: 10.1080/10495398.2018.1471401. Epub 2018 Jun 23.
Litter size is an important economic traits in pigs. gene is a member of (swine leukocyte antigen) complex. In our previous study, the gene was differentially expressed in PMSG-hCG stimulated preovulatory ovarian follicles of Chinese Taihu and Large White sows. Here, we identified two mutations (c.754-132 T > C and c.1421 + 38 T > C) in gene and analyzed the associations of two SNPs with litter size traits in Large White ( = 263) and DIV ( = 117) sows. The results showed that in Large White pigs, c.754-132 CC sows produced 0.74 and 0.87 more pigs per litter for TNB and NBA of all parities than did TT sows ( < .05); In DIV pigs, c.754-132 CC sows produced 1.17 more pigs per litter for TNB of all parities than did TC sows ( < .05). In Large White pigs, c.1421 + 38 CC sows produced 0.9 more pigs per litter for TNB of all parities than did TT sows ( < .05), while in DIV pigs c.1421 + 38 CC sows produced 0.84 and 0.7 less pigs per litter for TNB and NBA of all parities than did TT sows ( < .05). Our research indicated that mutations were potential molecular markers for improving the litter size traits in pigs.
产仔数是猪的一个重要经济性状。 基因是（猪白细胞抗原）复合体的一个成员。在我们之前的研究中，该基因在 PMSG-hCG 刺激的中国太湖和长白母猪的发情前卵巢卵泡中差异表达。在这里，我们在 基因中鉴定出两个突变（c.754-132 T > C 和 c.1421 + 38 T > C），并分析了两个 SNP 与长白（ = 263）和 DIV（ = 117）母猪产仔数性状的关系。结果表明，在长白猪中，c.754-132 CC 母猪比 TT 母猪在所有胎次的 TNB 和 NBA 中每窝多产 0.74 和 0.87 头仔猪（ < .05）；在 DIV 猪中，c.754-132 CC 母猪比 TC 母猪在所有胎次的 TNB 中每窝多产 1.17 头仔猪（ < .05）。在长白猪中，c.1421 + 38 CC 母猪比 TT 母猪在所有胎次的 TNB 中每窝多产 0.9 头仔猪（ < .05），而在 DIV 猪中，c.1421 + 38 CC 母猪比 TT 母猪在所有胎次的 TNB 和 NBA 中每窝少产 0.84 和 0.7 头仔猪（ < .05）。我们的研究表明， 突变是提高猪产仔数性状的潜在分子标记。
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