Samuel K G, Zhang H J, Wang J, Wu S G, Yue H Y, Sun L L, Qi G H
1Key Laboratory of Feed Biotechnology of Ministry of Agriculture,Feed Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081,China.
2Shanghai Medical Life Science Research Center Co. Ltd,Shanghai 200032,China.
Animal. 2015 Mar;9(3):409-16. doi: 10.1017/S1751731114002328. Epub 2014 Sep 17.
Pyrroloquinoline quinone (PQQ), a putative essential nutrient and redox modulator in microorganisms, cell and animal models, has been recognized as a growth promoter in rodents. Growth performance, carcass yield and antioxidant status were evaluated on broiler chickens fed different levels of PQQ disodium (PQQ.Na2). A total of 784 day-old male Arbor Acres (AA) broilers were randomly allotted into seven dietary groups: negative control group (NC) fed a basal diet without virginiamycin (VIR) or PQQ.Na2; a positive control group (PC) fed a diet with 15 mg of VIR/kg diet; and PQQ.Na2 groups fed with 0.05, 0.10, 0.20, 0.40 or 0.80 mg PQQ.Na2/kg diet. Each treatment contained eight replicates with 14 birds each. The feeding trial lasted for 6 weeks. The results showed that chicks fed 0.2 mg PQQ.Na2/kg diet significantly improved growth performance comparable to those in PC group, and the feed efficiency enhancement effects of dietary PQQ.Na2 was more apparent in grower phase. Dietary addition of PQQ.Na2 had the potential to stimulate immune organs development, and low level dietary addition (<0.1 mg/kg) increased plasma lysozyme level. Broilers fed 0.2 mg PQQ.Na2/kg diet gained more carcasses at day 42, and had lower lipid peroxide malondialdehyde content and higher total antioxidant power in plasma. The results indicated that dietary PQQ.Na2 (0.2 mg/kg diet) had the potential to act as a growth promoter comparable to antibiotic in broiler chicks.
吡咯喹啉醌（PQQ）是微生物、细胞和动物模型中一种假定的必需营养素和氧化还原调节剂，在啮齿动物中已被公认为一种生长促进剂。对饲喂不同水平吡咯喹啉醌二钠（PQQ·Na₂）的肉鸡的生长性能、胴体产量和抗氧化状态进行了评估。总共784只1日龄的雄性艾维茵（AA）肉鸡被随机分配到七个日粮组：阴性对照组（NC）饲喂不含维吉尼亚霉素（VIR）或PQQ·Na₂的基础日粮；阳性对照组（PC）饲喂含15 mg VIR/kg日粮的日粮；以及PQQ·Na₂组，分别饲喂0.05、0.10、0.20、0.40或0.80 mg PQQ·Na₂/kg日粮。每个处理包含8个重复，每个重复14只鸡。饲养试验持续6周。结果表明，饲喂0.2 mg PQQ·Na₂/kg日粮的雏鸡生长性能显著提高，与PC组相当，日粮中PQQ·Na₂对饲料效率的提高作用在生长阶段更为明显。日粮中添加PQQ·Na₂有刺激免疫器官发育的潜力，低水平日粮添加（<0.1 mg/kg）可提高血浆溶菌酶水平。饲喂0.2 mg PQQ·Na₂/kg日粮的肉鸡在42日龄时胴体增重更多，血浆中脂质过氧化物丙二醛含量更低，总抗氧化能力更高。结果表明，日粮中PQQ·Na₂（0.2 mg/kg日粮）有潜力作为一种与抗生素相当的生长促进剂用于肉鸡雏鸡。
