Çokçalışkan Can, Tuncer Göktuna Pelin, Türkoğlu Tunçer, Uzunlu Ergün, Gündüzalp Ceylan, Uzun Eylem Aras, Sareyyüpoğlu Beyhan, Kürkçü Ayça, Gülyaz Veli
Republic of Turkey Ministry of Agriculture and Forestry, Institute of Foot and Mouth Disease (SAP), Ankara, Turkey.
Clin Exp Vaccine Res. 2019 Jul;8(2):103-109. doi: 10.7774/cevr.2019.8.2.103. Epub 2019 Jul 31.
Foot-and-mouth disease (FMD) and anthrax are important diseases in sheep. Vaccination is a favorable strategy against both infections. Simultaneous administration of vaccines does generally not impede the immune responses of each other, although there are some exceptions, and it may help reduce the labor and costs of vaccination as well as distress on animals. Although oil adjuvant FMD vaccine has been tried with live anthrax vaccine in cattle, there are no reports on the simultaneous use of both vaccines in sheep.
In this study, FMD seronegative sheep were used to investigate the impact of the simultaneous vaccination of FMD and anthrax on FMD antibody titers of sheep. Virus neutralization test and liquid phase blocking enzyme-linked immunosorbent assay were used to determine the antibody response to the FMD vaccine.
The results demonstrated that both vaccines can be used simultaneously without any interference with the FMD response. Moreover, the simultaneous administration with anthrax vaccine had a stimulating effect on the early (day 7 post-vaccination) virus neutralization antibody response to the FMD vaccine.
The simultaneous use of the FMD and anthrax vaccines did not hinder the response to the FMD vaccine in sheep.
口蹄疫（FMD）和炭疽是绵羊的重要疾病。疫苗接种是预防这两种感染的有利策略。尽管存在一些例外情况，但同时接种疫苗通常不会相互妨碍免疫反应，并且这可能有助于减少疫苗接种的劳动力和成本以及动物的痛苦。虽然油佐剂口蹄疫疫苗已在牛中与活炭疽疫苗一起试用，但尚无关于在绵羊中同时使用这两种疫苗的报道。
在本研究中，使用口蹄疫血清阴性绵羊来研究同时接种口蹄疫和炭疽疫苗对绵羊口蹄疫抗体滴度的影响。采用病毒中和试验和液相阻断酶联免疫吸附试验来测定对口蹄疫疫苗的抗体反应。
结果表明，两种疫苗可以同时使用，而不会对口蹄疫反应产生任何干扰。此外，与炭疽疫苗同时接种对口蹄疫疫苗早期（接种后第7天）的病毒中和抗体反应有刺激作用。
同时使用口蹄疫和炭疽疫苗不会妨碍绵羊对口蹄疫疫苗的反应。
