Daneva Zdravka, Laubach Victor E, Sonkusare Swapnil K
Robert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, 22908, USA.
Department of Surgery, University of Virginia-School of Medicine, Charlottesville, VA, 22908, USA.
Curr Opin Physiol. 2019 Jun;9:87-93. doi: 10.1016/j.cophys.2019.04.026. Epub 2019 May 9.
Dysregulated redox signaling in pulmonary vasculature is central to the development of pulmonary arterial hypertension (PAH) and lung injury. Modulators of reactive oxygen species (ROS) production and downstream signaling targets are critical for mediating the physiological or pathological effects of ROS. Understanding the complex interactions between the modulators and signaling targets of ROS is essential for developing novel strategies to prevent or attenuate lung pathologies. In this review, we discuss recent studies on the modulators and targets of ROS in pulmonary endothelial and smooth muscle cells, their cellular effects, and the disease conditions associated with dysregulated redox signaling.
肺血管中氧化还原信号失调是肺动脉高压（PAH）和肺损伤发展的核心。活性氧（ROS）产生的调节剂和下游信号靶点对于介导ROS的生理或病理作用至关重要。了解ROS调节剂与信号靶点之间的复杂相互作用对于开发预防或减轻肺部病变的新策略至关重要。在这篇综述中，我们讨论了关于肺内皮细胞和平滑肌细胞中ROS调节剂和靶点的最新研究、它们的细胞效应以及与氧化还原信号失调相关的疾病状况。
