Department of Psychiatry, Brigham and Women's Hospital, 221 Longwood Avenue, BLI442, 75 Francis St, Boston, MA, 02115, USA.
Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA.
Brain Struct Funct. 2019 Nov;224(8):2603-2617. doi: 10.1007/s00429-019-01932-7. Epub 2019 Aug 12.
The human eye movement network is a complex system that requires the integration of sensory, motor, attentional, and executive processes. Here, we review the neuroanatomy of the eye movement network with an emphasis on functional neuroimaging applications. We consolidate the literature into a concise resource designed to be immediately accessible and applicable to diverse research interests, and present the novel Functional Oculomotor System (FOcuS) Atlas-a tool in stereotaxic space that will simplify and standardize the inclusion of the eye movement network in future functional neuroimaging studies. We anticipate this review and the FOcuS Atlas will facilitate increased examination of the eye movement network across disciplines leading to a thorough understanding of how eye movement network function contributes to higher-order cognition and how it is integrated with other brain networks. Furthermore, functional examination of the eye movement network in patient populations offers the potential for deeper insight into the role of eye movement circuitry in functional network activity, diagnostic assessments, and the indications for augmentative communication systems that rely on eye movement control.
人类眼球运动网络是一个复杂的系统，需要整合感觉、运动、注意和执行过程。在这里，我们重点介绍了眼球运动网络的神经解剖结构及其在功能神经影像学中的应用。我们将文献整合为一个简洁的资源，旨在使其易于访问并适用于各种研究兴趣，并介绍了新颖的功能性眼球运动系统（FOcuS）图谱——这是一种在立体定向空间中的工具，将简化和标准化眼球运动网络在未来功能神经影像学研究中的纳入。我们预计，本综述和 FOcuS 图谱将促进跨学科对眼球运动网络的进一步研究，从而深入了解眼球运动网络功能如何有助于更高阶的认知，以及它如何与其他大脑网络相整合。此外，对患者群体的眼球运动网络进行功能检查，有可能深入了解眼球运动回路在功能网络活动、诊断评估以及依赖眼球运动控制的增强型交流系统中的作用。
