二甲基亚砜对人肝癌HepG2细胞血浆蛋白合成的影响。诱导急性期样反应。
Effects of dimethyl sulphoxide on the synthesis of plasma proteins in the human hepatoma HepG2. Induction of an acute-phase-like reaction.
作者信息
Iwasa F, Galbraith R A, Sassa S
机构信息
Rockefeller University Hospital, New York, NY 10021.
出版信息
Biochem J. 1988 Aug 1;253(3):927-30. doi: 10.1042/bj2530927.
Abstract
Effects of dimethyl sulphoxide (Me2SO) on the synthesis of plasma proteins by the human hepatoma cell line HepG2 were examined. Me2SO treatment resulted in decreased synthesis of albumin and alpha-fetoprotein, and in increased synthesis of haptoglobin. Plasma-protein profiles induced by Me2SO treatment were very similar to those seen in acute-phase reactions.
摘要
研究了二甲基亚砜（Me2SO）对人肝癌细胞系HepG2合成血浆蛋白的影响。Me2SO处理导致白蛋白和甲胎蛋白的合成减少，而触珠蛋白的合成增加。Me2SO处理诱导的血浆蛋白谱与急性期反应中所见的非常相似。
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