Department of Dermatology, Hospital Universitario La Zarzuela, 28023 Madrid, Spain.
Acta Derm Venereol. 2019 Nov 1;99(12):1099-1104. doi: 10.2340/00015555-3286.
Frontal fibrosing alopecia has been related to some autoimmune diseases, but the association with rosacea is not clear. The objective of this study was to analyse the prevalence of rosacea in a group of patients with frontal fibrosing alopecia. A cross-sectional study, including 99 women with frontal fibrosing alopecia and 40 controls, was performed, in which clinical, dermoscopic and hormonal data were analysed. Women with frontal fibrosing alopecia presented a higher prevalence of rosacea than the controls did (61.6% vs. 30%, p = 0.001), especially those with severe grades of alopecia (77.8% in grade V vs. 33.3% in grade I, p = 0.02). Binary logistic multivariate analysis showed that perifollicular erythema (odds ratio (OR) 8.5; 95% confidence interval (95% CI) 1.73-42.30), higher body mass index (OR 1.16; 95% CI 1.01-1.34) and lower progesterone levels (OR 0.15; 95% CI 0.028-0.89) were associated with a higher risk of rosacea in patients with frontal fibrosing alopecia. In conclusion, patients with frontal fibrosing alopecia presented a higher prevalence of rosacea than did controls. Perifollicular erythema, higher body mass index and lower progesterone levels were associated with a higher risk of rosacea in the group with frontal fibrosing alopecia.
额部纤维性脱发与某些自身免疫性疾病有关，但与酒渣鼻的关联尚不清楚。本研究的目的是分析一组额部纤维性脱发患者中酒渣鼻的患病率。进行了一项横断面研究，包括 99 名额部纤维性脱发女性和 40 名对照者，分析了临床、皮肤镜和激素数据。与对照组相比，额部纤维性脱发女性的酒渣鼻患病率更高（61.6%比 30%，p=0.001），尤其是脱发严重程度为 V 级的患者（77.8%比 I 级的 33.3%，p=0.02）。二元逻辑多元分析显示，毛囊周围红斑（比值比（OR）8.5；95%置信区间（95%CI）1.73-42.30）、较高的体重指数（OR 1.16；95%CI 1.01-1.34）和较低的孕激素水平（OR 0.15；95%CI 0.028-0.89）与额部纤维性脱发患者发生酒渣鼻的风险增加相关。总之，额部纤维性脱发患者的酒渣鼻患病率高于对照组。毛囊周围红斑、较高的体重指数和较低的孕激素水平与额部纤维性脱发患者发生酒渣鼻的风险增加相关。
