Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, PR China; Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
Semin Cell Dev Biol. 2020 May;101:41-50. doi: 10.1016/j.semcdb.2019.07.014. Epub 2019 Sep 10.
Autophagy is a conserved intracellular degradation process enclosing the bulk of cytosolic components for lysosomal degradation to maintain cellular homeostasis. Accumulating evidences showed that a specialized form of autophagy, known as xenophagy, could serve as an innate immune response to defend against pathogens invading inside the host cells. Correspondingly, infectious pathogens have developed a variety of strategies to disarm xenophagy, leading to a prolonged and persistent intracellular colonization. In this review, we first summarize the current knowledge about the general mechanisms of intracellular bacterial infections and xenophagy. We then focus on the ongoing battle between these two processes.
自噬是一种保守的细胞内降解过程，它将细胞质中的大部分成分包裹起来进行溶酶体降解，以维持细胞内的稳态。越来越多的证据表明，一种特殊形式的自噬，即异噬作用，可以作为一种先天免疫反应来抵抗宿主细胞内入侵的病原体。相应地，传染性病原体已经发展出多种策略来破坏异噬作用，从而导致细胞内持续和持久的定植。在这篇综述中，我们首先总结了关于细胞内细菌感染和异噬作用的一般机制的现有知识。然后，我们将重点介绍这两个过程之间的持续斗争。
