Niu Fuqiu, Chong Shigui, Qin Mingqun, Li Shenmei, Wei Riming, Zhao Yumin
Department of Parasitology, School of Basic Medicine, Guilin Medical University, Guangxi 541004, China.
School of Stomatology, Guilin Medical University, Guangxi 541004, China.
Diseases. 2019 Aug 12;7(3):51. doi: 10.3390/diseases7030051.
Infection with spp. causes fibrosis in various vital organs, including the liver and lungs. Hepatic fibrosis is a pathological feature of infection that destroys normal liver tissue, leading to jaundice, cholecystitis, portal hypertension, etc. Severe infections lead to liver failure and hepatic encephalopathy. The formation of peripheral fiberboards around the metacestode is a major reason as to why antiparasitic drugs fail to be effectively transported to the lesion site. Studies on the mechanism of hepatic fibrosis caused by are important for treatment in patients. Recent studies have focused on miRNA and TGF-β. More recent findings have focused on the generation of collagen fibers around the metacestode. In this review paper we focus on the mechanism by which the Echinococcus parasite induces fibrosis in liver and some other organs in intermediate hosts-animals as well as human beings.
感染 属物种会在包括肝脏和肺在内的各种重要器官中引发纤维化。肝纤维化是 感染的一种病理特征，它会破坏正常肝组织，导致黄疸、胆囊炎、门静脉高压等。严重的 感染会导致肝衰竭和肝性脑病。成虫周围形成外周纤维板是抗寄生虫药物无法有效转运至病变部位的主要原因。对 所致肝纤维化机制的研究对患者的治疗很重要。近期研究聚焦于微小RNA和转化生长因子-β。更新的研究发现则聚焦于成虫周围胶原纤维的生成。在这篇综述论文中，我们关注棘球绦虫寄生虫在中间宿主（动物以及人类）的肝脏和其他一些器官中诱导纤维化的机制。
