Liance M, Ricard-Blum S, Emery I, Houin R, Vuitton D A
Laboratoire de Parasitologie, Faculté de Médecine, Créteil, France.
Parasite. 1998 Sep;5(3):231-7. doi: 10.1051/parasite/1998053231.
As no antiparasitic drug is definitively efficient in patients with alveolar echinococcosis, the effects of exogenous IFN-gamma on murine Echinococcus multilocularis infection were assessed with regards to the parasite burden, parasite-specific immune responses, and the urinary level of the collagen cross-link pyridinolines. They were analyzed after 3-week treatments with 1 or 5 micrograms of IFN-gamma per day twice a week. The treatment with 1 microgram transiently reduced the liver metacestode load, and the metastase weight as far as 6 weeks after the end of treatment. It slightly increased Th 1-type T cell responses and reduced the excretion of pyridinolines. These results should encourage further study to assess whether the decrease in liver fibrosis leads to an improvement of the efficacy of albendazole therapy. In contrast, the treatment with 5 micrograms increased the liver metacestode load and was less efficient than that with 1 microgram in decreasing pyridinoline excretion. These results incitate to follow up carefully patients with alveolar echinococcosis who are treated with IFN-gamma.
由于没有抗寄生虫药物对肺泡型棘球蚴病患者有绝对疗效，因此针对寄生虫负荷、寄生虫特异性免疫反应以及胶原交联吡啶啉的尿液水平，评估了外源性干扰素-γ对小鼠多房棘球绦虫感染的影响。在每周两次、每次用1或5微克干扰素-γ进行3周治疗后对其进行分析。1微克剂量的治疗在治疗结束后长达6周的时间内可短暂降低肝脏中绦虫囊负荷和转移灶重量。它略微增加了Th1型T细胞反应，并减少了吡啶啉的排泄。这些结果应促使进一步研究，以评估肝纤维化的减轻是否会导致阿苯达唑治疗效果的改善。相比之下，5微克剂量的治疗增加了肝脏中绦虫囊负荷，在减少吡啶啉排泄方面不如1微克剂量有效。这些结果促使对接受干扰素-γ治疗的肺泡型棘球蚴病患者进行仔细随访。
