Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, China.
BMC Ophthalmol. 2019 Aug 13;19(1):182. doi: 10.1186/s12886-019-1194-y.
To compare and correlate anterior segment measurements of myopic eyes implanted with Implantable Collamer lens (ICL V4c) by using anterior segment optical coherence tomography (AS-OCT), Pentacam and ultrasound biomicroscopy (UBM).
Anterior chamber depth (ACD), distance between corneal endothelium and anterior surface of ICL(C-ICL) and central vault were measured in 82 phakic myopic eyes of 82 patients who underwent ICL surgery, by using AS-OCT, Pentacam and UBM consecutively at 3 months follow up. The correlation and agreement of instruments were accessed by using Intraclass correlation coefficient (ICC) and the Bland-Altman plot.
AS-OCT showed higher ACD, C -ICL and central vault measurements than both of Pentacam and UBM (P < 0.001), while Pentacam showed lower measurements than UBM (P < 0.05). The Pearson correlation coefficient (r) was 0.91 to 0.96, and ICC was 0.95 to 0.98 for all measurements between difference devices (all P < 0.001). The 95% limits of agreement of ACD, C-ICL, vault measurements were 0.13 to 0.38 mm, - 0.07 to 0.27 mm, 0.08 to 0.34 mm between AS-OCT and Pentacam, - 0.03 to 0.33 mm, - 0.16 to 0.31 mm, - 0.10 to 0.26 mm between AS-OCT and UBM, and - 0.29 to 0.07 mm, - 0.25 to 0.20 mm, - 0.31 to 0.05 mm between Pentacam and UBM, respectively.
AS-OCT demonstrated significantly higher value, while Pentacam demonstrated significantly lower value than UBM for ACD, C-ICL and central vault measurements in myopic eyes after ICL surgery. Measurements with these instruments were highly correlated, but could not replace each other especially for vault. This study provided valuable information about how to judge the results of anterior segment parameters of eyes implanted with ICL V4c from different devices.
Registration number: ChiCTR-OOC-16008987 . Retrospectively registered: 08 August 2016.
比较并分析植入可植入 Collamer 透镜（ICL V4c）的近视眼的眼前节测量值，使用眼前节光学相干断层扫描（AS-OCT）、Pentacam 和超声生物显微镜（UBM）。
连续 3 个月对 82 例接受 ICL 手术的 82 例近视患者的 82 只眼进行眼前节深度（ACD）、角膜内皮与 ICL 前表面之间的距离（C-ICL）和中央拱顶的测量，分别采用 AS-OCT、Pentacam 和 UBM。采用组内相关系数（ICC）和 Bland-Altman 图评估仪器的相关性和一致性。
AS-OCT 显示 ACD、C-ICL 和中央拱顶的测量值均高于 Pentacam 和 UBM（P<0.001），而 Pentacam 的测量值低于 UBM（P<0.05）。差异设备之间的 Pearson 相关系数（r）为 0.91 至 0.96，ICC 为 0.95 至 0.98（均 P<0.001）。ACD、C-ICL、拱顶测量的 95%一致性界限为 0.13 至 0.38mm、-0.07 至 0.27mm、0.08 至 0.34mm 之间为 AS-OCT 和 Pentacam，-0.03 至 0.33mm、-0.16 至 0.31mm、-0.10 至 0.26mm 之间为 AS-OCT 和 UBM，-0.29 至 0.07mm、-0.25 至 0.20mm、-0.31 至 0.05mm 之间为 Pentacam 和 UBM。
在 ICL 手术后的近视眼中，AS-OCT 显示 ACD、C-ICL 和中央拱顶的测量值明显高于 UBM，而 Pentacam 显示的测量值明显低于 UBM。这些仪器的测量值高度相关，但不能相互替代，尤其是拱顶的测量值。本研究为如何从不同设备判断植入 ICL V4c 后眼前节参数的结果提供了有价值的信息。
注册号：ChiCTR-OOC-16008987。回顾性注册：2016 年 8 月 8 日。
