南美人口最密集大都市地区淋病奈瑟菌临床分离株中抗菌药物耐药性的时间演变
Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region.
作者信息
Martins Rafael Affini, Cassu-Corsi Dandara, Nodari Carolina Silva, Cayô Rodrigo, Natsumeda Larissa, Streling Ana Paula, Doi André Mario, da Silva Roberto José Carvalho, Bocalon Roberta Alessandra Lima, Gales Ana Cristina, Pignatari Antonio Carlos Campos
机构信息
Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina, Laboratório ALERTA, São Paulo, SP, Brasil.
Universidade Federal de São Paulo, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Departamento de Ciências Biológicas, Laboratório de Bacteriologia e Imunologia, Diadema, SP, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2019;114:e190079. doi: 10.1590/0074-02760190079. Epub 2019 Aug 12.
A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes).
对2003年至2015年这12年间从巴西圣保罗市艾滋病/性传播感染参考与培训中心协助治疗的门诊患者中分离出的124株淋病奈瑟菌进行了分析。观察到以下耐药率：青霉素-59.6%，环丙沙星-15.3%，阿奇霉素-6.7%。尽管自2003年以来观察到对这些药物的敏感性降低，但未检测到对头孢曲松耐药的分离株。环丙沙星和阿奇霉素不敏感的分离株被分为11个簇。在分离株124和260的GyrA和ParC中检测到突变，在分离株260中还观察到23S rRNA等位基因上的C2611T替换。这两个分离株均属于ST1901/ST6210（MSLT/NG-MAST分型方案）。
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