León P, López J A, Contreras G, Echevarría J M
Centro Nacional de Microbiología, Virología e Inmunología Sanitarias, Madrid, Spain.
Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):533-5.
In a study to determine the incidence of infection with hepatitis delta virus (HDV) in high-risk groups in Spain, tests to detect serological markers of infection with hepatitis B virus (HBV) and total antibodies against HDV (anti-HDV) were performed in serum samples from 451 unselected intravenous drug addicts and 168 homosexual or bisexual men. Most samples were obtained from primary health care units in Madrid. In drug addicts 87.4% of samples were positive for HBV markers and 15.1% were positive for anti-HDV. However, the incidence of anti-HD was much higher in HBsAg carriers (70.7%) than in individuals positive for anti-HBs (10.4%). Ninety-two samples (54.8%) from homosexual men were positive for HBV markers, but all were negative for anti-HD. Thus, parenteral transmission seems to play a major role in the spread of HDV in Spain, the sexual route being of minor relevance.
在一项确定西班牙高危人群中丁型肝炎病毒（HDV）感染率的研究中，对来自451名未经挑选的静脉注射吸毒者和168名男同性恋者或双性恋男性的血清样本进行了检测，以检测乙型肝炎病毒（HBV）感染的血清学标志物和抗HDV总抗体（抗HDV）。大多数样本取自马德里的初级卫生保健机构。在吸毒者中，87.4%的样本HBV标志物呈阳性，15.1%的样本抗HDV呈阳性。然而，HBsAg携带者中抗HD的发生率（70.7%）远高于抗HBs阳性者（10.4%）。来自男同性恋者的92份样本（54.8%）HBV标志物呈阳性，但所有样本抗HD均为阴性。因此，在西班牙，肠道外传播似乎在HDV传播中起主要作用，性传播途径的相关性较小。
