重组鼠γ干扰素在体外或体内激活小鼠腹腔巨噬细胞可抑制沙眼衣原体L1血清型的生长。
Activation of mouse peritoneal macrophages in vitro or in vivo by recombinant murine gamma interferon inhibits the growth of Chlamydia trachomatis serovar L1.
作者信息
Zhong G M, de la Maza L M
机构信息
Department of Pathology, University of California, Irvine 92717.
出版信息
Infect Immun. 1988 Dec;56(12):3322-5. doi: 10.1128/iai.56.12.3322-3325.1988.
Abstract
Peritoneal mouse macrophages activated in vitro with recombinant murine gamma interferon (10 ng/ml) or in vivo (10 micrograms per mouse) showed a significant decrease in the growth and yield of Chlamydia trachomatis. The restriction of the growth of C. trachomatis paralleled the expression of Iad on the macrophages. Mice that received macrophages activated in vitro with recombinant murine gamma interferon showed a significant decrease in the yield of chlamydial infection-forming units from their spleens and peritoneal fluids.
摘要
用重组鼠γ干扰素（10纳克/毫升）在体外激活或在体内（每只小鼠10微克）激活的腹膜小鼠巨噬细胞，沙眼衣原体的生长和产量显著降低。沙眼衣原体生长的受限与巨噬细胞上Iad的表达平行。接受用重组鼠γ干扰素在体外激活的巨噬细胞的小鼠，其脾脏和腹膜液中衣原体感染形成单位的产量显著降低。
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Activation of mouse peritoneal macrophages in vitro or in vivo by recombinant murine gamma interferon inhibits the growth of Chlamydia trachomatis serovar L1.重组鼠γ干扰素在体外或体内激活小鼠腹腔巨噬细胞可抑制沙眼衣原体L1血清型的生长。
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本文引用的文献
1
Growth of meningopneumonitis virus in normal and immune guinea pig monocytes.脑膜炎肺炎病毒在正常及免疫豚鼠单核细胞中的生长
Nature. 1958 Jun 21;181(4625):1742-3. doi: 10.1038/1811742a0.
2
Inhibition of Chlamydia psittaci in oxidatively active thioglycolate-elicited macrophages: distinction between lymphokine-mediated oxygen-dependent and oxygen-independent macrophage activation.氧化活性巯基乙酸盐诱导的巨噬细胞中鹦鹉热衣原体的抑制作用：淋巴因子介导的氧依赖性和非氧依赖性巨噬细胞活化之间的区别。
Infect Immun. 1983 May;40(2):464-71. doi: 10.1128/iai.40.2.464-471.1983.
3
Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity.具有免疫干扰素活性的淋巴因子对小鼠巨噬细胞Ia抗原表达的调节。
J Exp Med. 1982 Dec 1;156(6):1780-93. doi: 10.1084/jem.156.6.1780.
4
Effect of IFN-gamma on the immune response in vivo and on gene expression in vitro.γ干扰素对体内免疫反应及体外基因表达的影响。
Nature. 1984;307(5949):381-2. doi: 10.1038/307381a0.
5
Association of an inflammatory I region-associated antigen-positive macrophage influx and genetic resistance of inbred mice to Rickettsia tsutsugamushi.炎症性I区相关抗原阳性巨噬细胞浸润与近交系小鼠对恙虫病立克次体的遗传抗性之间的关联。
Infect Immun. 1983 Nov;42(2):549-57. doi: 10.1128/iai.42.2.549-557.1983.
6
7
Colony formation by mouse peritoneal exudate cells in vitro.小鼠腹腔渗出细胞的体外集落形成
Nat New Biol. 1973 Jun 6;243(127):176-7. doi: 10.1038/newbio243176a0.
8
Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.γ干扰素对小鼠腹腔巨噬细胞的体内外激活作用
J Immunol. 1985 Mar;134(3):1619-22.
9
Fate of Chlamydia trachomatis in human monocytes and monocyte-derived macrophages.沙眼衣原体在人单核细胞及单核细胞来源巨噬细胞中的命运
Infect Immun. 1986 Oct;54(1):90-5. doi: 10.1128/iai.54.1.90-95.1986.
10
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Infect Immun. 1988 Jan;56(1):283-6. doi: 10.1128/iai.56.1.283-286.1988.
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