Su Yanping, Qiu Ye, Qiu Zhidong, Qu Peng
Department of Histology and embryology, Shangdong First Medical University & Shangdong Academy of Medical Sciences, Taian, Shangdong, China.
National Engineering Lab for Druggable gene and protein screening, Northeast Normal University, Changchun, Jilin, China.
J Cancer. 2019 Jul 10;10(18):4350-4356. doi: 10.7150/jca.35205. eCollection 2019.
Myeloid-derived suppressor cells (MDSCs), one heterogeneous population of immature myeloid cells, have suppressive function on immune response during tumor, inflammation, infection and autoimmune diseases. The molecular mechanism underlying expansion and function of MDSCs is becoming appreciated to manipulate immune response in the diseases. MicroRNA (miRNAs) as one short noncoding RNAs, are involved in regulating cell proliferation, differentiation and maturation. However, it needs to be further studied how miRNAs mediate the development and function of MDSC in association with cancer and other diseases. In the review, we report and discuss recent studies that miRNAs networks regulate the differentiation, expansion and suppression function of MDSCs in tumor microenvironment or other diseases through different signaling pathways. Those studies may provide one novel potential approach for tumor immunotherapy.
髓系来源的抑制细胞（MDSCs）是未成熟髓系细胞的一个异质性群体，在肿瘤、炎症、感染和自身免疫性疾病期间对免疫反应具有抑制功能。MDSCs扩增和功能的分子机制在调控这些疾病中的免疫反应方面正逐渐受到重视。微小RNA（miRNAs）作为一类短链非编码RNA，参与调节细胞增殖、分化和成熟。然而，miRNAs如何与癌症及其他疾病相关联介导MDSC的发育和功能，仍有待进一步研究。在本综述中，我们报告并讨论了近期的研究，即miRNAs网络通过不同信号通路在肿瘤微环境或其他疾病中调节MDSCs的分化、扩增和抑制功能。这些研究可能为肿瘤免疫治疗提供一种新的潜在方法。
