Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.
Laboratory of Virology, Department of Plant Sciences, Wageningen University & Research, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands.
Mol Plant Microbe Interact. 2020 Jan;33(1):40-54. doi: 10.1094/MPMI-06-19-0161-FI. Epub 2019 Nov 11.
RNA granules are dynamic cellular foci that are widely spread in eukaryotic cells and play essential roles in cell growth and development, and immune and stress responses. Different types of granules can be distinguished, each with a specific function and playing a role in, for example, RNA transcription, modification, processing, decay, translation, and arrest. By means of communication and exchange of (shared) components, they form a large regulatory network in cells. Viruses have been reported to interact with one or more of these either cytoplasmic or nuclear granules, and act either proviral, to enable and support viral infection and facilitate viral movement, or antiviral, protecting or clearing hosts from viral infection. This review describes an overview and recent progress on cytoplasmic and nuclear RNA granules and their interplay with virus infection, first in animal systems and as a prelude to the status and current developments on plant viruses, which have been less well studied on this thus far.
RNA 颗粒是广泛存在于真核细胞中的动态细胞焦点，在细胞生长和发育、免疫和应激反应中发挥着重要作用。不同类型的颗粒可以区分开来，每种都具有特定的功能，并在 RNA 转录、修饰、加工、降解、翻译和阻滞等方面发挥作用。通过通信和（共享）组件的交换，它们在细胞中形成一个大型的调控网络。据报道，病毒与一个或多个细胞质或核 RNA 颗粒相互作用，作用方式要么是促进病毒，以促进和支持病毒感染并促进病毒运动，要么是抗病毒，保护或清除宿主免受病毒感染。本综述描述了细胞质和核 RNA 颗粒及其与病毒感染相互作用的概述和最新进展，首先在动物系统中进行描述，然后介绍植物病毒的现状和最新进展，迄今为止，植物病毒在这方面的研究较少。
