Yang Jiao, Jiang Yilu, Chen Ying, Sun Mingsheng, Chen Jiao, Zheng QianHua, Liang Fan-Rong
Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Medicine (Baltimore). 2019 Aug;98(33):e16857. doi: 10.1097/MD.0000000000016857.
Postoperative nausea and vomiting (PONV) are common complications following surgery and anesthesia, conventional drugs can carry some side effect in treating PONV. Acupressure PC6 point has been widely used in clinical, but there still exist controversy towards its effectiveness and safety. We, therefore, design this study to systematically assess the effectiveness and safety of acupressure PC6 point for treating PONV.
Nine online databases will be searched from their inception to May 2019. We will include randomized controlled trials (RCTs) involving patients with PONV and receiving acupressure PC6 point treatment. Two independent reviewers will be responsible for the selection of studies, data extraction and risk of bias assessment. RevMan V.5.3 software will be used for data synthesis with either a fixed effects model or random effects model depending on the heterogeneity test. Evidence quality will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation system (GRADE). The primary outcome is incidence of postoperative nausea (PON), postoperative vomiting (POV) and PONV events during 0 to 6 hours and after 6 hours of the treatment. The secondary outcome is the number of people who use emergency drugs and the number of people with adverse reactions. A meta-analysis will be conducted if no considerable heterogeneity is detected. The results will be presented as risk ratios with 95% confidence interval (CIs) for dichotomous data and weighted mean differences or standardized mean differences with 95% CIs for continuous data.
This study will provide a high-quality evidence to assess the effectiveness and safety of acupressure PC6 point for patient with PONV.
This review will provide up-date evidence of whether acupressure of PC6 point is an effective and safe intervention for PONV. PROSPERO registration number: CRD42019135598.
术后恶心呕吐（PONV）是手术和麻醉后的常见并发症，传统药物治疗 PONV 可能会带来一些副作用。按压内关穴已在临床中广泛应用，但对于其有效性和安全性仍存在争议。因此，我们设计本研究以系统评估按压内关穴治疗 PONV 的有效性和安全性。
将检索九个在线数据库，检索时间从建库至 2019 年 5 月。我们将纳入涉及 PONV 患者并接受按压内关穴治疗的随机对照试验（RCT）。两名独立的评审员将负责研究的筛选、数据提取和偏倚风险评估。将根据异质性检验结果，使用 RevMan V.5.3 软件采用固定效应模型或随机效应模型进行数据合成。将使用推荐分级评估、制定与评价系统（GRADE）评估证据质量。主要结局是治疗后 0 至 6 小时及 6 小时后术后恶心（PON）、术后呕吐（POV）和 PONV 事件的发生率。次要结局是使用急救药物的人数和出现不良反应的人数。如果未检测到显著异质性，则将进行荟萃分析。结果将以二分类数据的风险比及 95%置信区间（CI）呈现，连续数据则以加权均数差或标准化均数差及 95%CI 呈现。
本研究将为评估按压内关穴治疗 PONV 患者的有效性和安全性提供高质量证据。
本综述将提供关于按压内关穴是否为 PONV 的有效且安全干预措施的最新证据。PROSPERO 注册号：CRD42019135598。
