Wicaksono Beni, Hadian Feriana Ira, Firdaus Achmad Dafir, Ulhaq Zulvikar Syambani
Nursing Program, STIKES Maharani, Malang, Indonesia.
Research Center for Pre-Clinical and Clinical Medicine, National Research and Innovation Agency Republic of Indonesia, Cibinong, Indonesia.
J Ayurveda Integr Med. 2023 Sep-Oct;14(5):100794. doi: 10.1016/j.jaim.2023.100794. Epub 2023 Sep 7.
Patients with breast cancer are reported to experience nausea and vomiting during neoadjuvant chemotherapy. Both remain the most troubling side effects of chemotherapy, even in the era of new antiemetic agents. Hence, our study aims to investigate the clinical outcome of acupressure in the prevention of acute chemotherapy-induced nausea (CIN) by evaluating the frequency and severity of nausea. This study was a randomized controlled trial consisting of 42 breast cancer patients, divided equally into two groups (experimental (acupressure) and control groups). Digital acupressure was performed at pericardium 6 (P6 or Neiguan) and stomach 36 (ST36 or Zusanli) points. Assessment of nausea was conducted by examining the frequency of nausea and measuring nausea-related subscores from the simulator sickness questionnaire (SSQ) and visual analog scale (VAS) within one hour after chemotherapy. Our study indicated that patients in the experimental group had significantly lower frequency and less severe nausea than those in the control group. In conclusion, acupressure effectively decreased the frequency and severity of nausea in breast cancer patients undergoing neoadjuvant chemotherapy. Acupressure could be implemented as an adjunct intervention in addition to antiemetic therapy for the prevention of CIN in breast cancer patients.
据报道，乳腺癌患者在新辅助化疗期间会出现恶心和呕吐。即使在新型止吐药物的时代，这两种症状仍然是化疗最令人困扰的副作用。因此，我们的研究旨在通过评估恶心的频率和严重程度，调查指压法预防急性化疗引起的恶心（CIN）的临床效果。本研究是一项随机对照试验，由42名乳腺癌患者组成，平均分为两组（实验组（指压法）和对照组）。在心包经6穴（P6或内关）和胃经36穴（ST36或足三里）进行数字指压。化疗后1小时内，通过检查恶心频率以及从模拟器晕动病问卷（SSQ）和视觉模拟量表（VAS）测量与恶心相关的子分数来评估恶心情况。我们的研究表明，实验组患者的恶心频率明显低于对照组，且恶心程度较轻。总之，指压法可有效降低接受新辅助化疗的乳腺癌患者的恶心频率和严重程度。除了止吐治疗外，指压法可作为一种辅助干预措施，用于预防乳腺癌患者的CIN。
