Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
Department of Oral Anatomy, Aichi Gakuin University School of Dentistry, Nagoya, Japan.
Tissue Eng Part C Methods. 2019 Sep;25(9):513-522. doi: 10.1089/ten.TEC.2019.0143. Epub 2019 Sep 11.
The rat palatine fissure is anatomically similar to human alveolar cleft. In this study, we examined potential bone repair by an autologous bone implant and beta-tricalcium phosphate (β-TCP) using rat palatine fissure as a model. Autologous bone chips or β-TCP granules were implanted into the rat palatine fissure. Our model demonstrated that higher bone volume and bone mineral density were achieved with autologous bone graft than with β-TCP. We have provided the first demonstration of the suitability of the rat palatine fissure as the implant site to simulate the transplantation of bone graft materials into human alveolar cleft.
腭裂缝在解剖学上与人类牙槽裂相似。在这项研究中，我们使用腭裂缝作为模型，研究了自体骨植入物和β-磷酸三钙（β-TCP）的潜在骨修复作用。将自体骨片或β-TCP 颗粒植入大鼠腭裂缝中。我们的模型表明，自体骨移植物的骨量和骨密度高于β-TCP。我们首次证明了腭裂缝适合作为植入部位，以模拟骨移植材料移植到人类牙槽裂中的情况。
