Lefevre J C, Gaubert E, Tempesta M C, Lareng M B
Groupe d'Etude et Prévention des Maladies Transmissibles Sexuellement, Faculté de Médecine Toulouse-Purpan.
Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):635-8.
The minimal inhibitory concentration (MIC) of twelve antibiotics was determined by the method of dilution in agar for 50 non penicillinase-producing and 15 penicillinase-producing Neisseria gonorrhoeae (PPNG) strains. The commonly used antibiotics are active in vitro against all the strains. For the non PPNG stains, no difference was observed between the MICs with a previous investigation, in 1980. New quinolones are highly active against all the strains tested but two, with decreased sensitivity. Since 1980, 16 PPNG strains were isolated (2.2%) and analysed for plasmid content. Asian type plasmid (7.4 kb) was present in 9 strains and african type (5.3 kb) in 7 strains. The conjugative plasmid (39 kb) was present in 5 strains and the cryptic plasmid (4.4 kb) in all the strains.
采用琼脂稀释法测定了50株非产青霉素酶淋病奈瑟菌和15株产青霉素酶淋病奈瑟菌（PPNG）对12种抗生素的最低抑菌浓度（MIC）。常用抗生素在体外对所有菌株均有活性。对于非PPNG菌株，1980年的一项先前调查结果显示其MIC与本次无差异。新型喹诺酮类药物对所有测试菌株均有高度活性，但有两株敏感性降低。自1980年以来，共分离出16株PPNG菌株（2.2%）并分析其质粒含量。9株含有亚洲型质粒（7.4 kb），7株含有非洲型质粒（5.3 kb）。5株含有接合质粒（39 kb），所有菌株均含有隐蔽质粒（4.4 kb）。
