Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40-hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target.
作者信息
Sauvet Fabien, Erblang Mégane, Gomez-Merino Danielle, Rabat Arnaud, Guillard Mathias, Dubourdieu Dominique, Lefloch Hervé, Drogou Catherine, Van Beers Pascal, Bougard Clément, Bourrrilhon Cyprien, Arnal Pierrick, Rein Werner, Mouthon Franck, Brunner-Ferber Francoise, Leger Damien, Dauvilliers Yves, Chennaoui Mounir, Charvériat Mathieu
机构信息
Unité Fatigue et Vigilance, Institut de recherche biomédicale des armées (IRBA), Brétigny sur Orge, France.
EA 7330 VIFASOM, Hôtel Dieu, Université de Paris, Paris, France.
出版信息
Br J Clin Pharmacol. 2019 Nov;85(11):2623-2633. doi: 10.1111/bcp.14098. Epub 2019 Sep 15.
Abstract
摘要
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Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40-hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target.THN102（莫达非尼与氟卡尼的组合）对健康受试者40小时完全睡眠剥夺期间警觉性和认知的疗效：胶质连接蛋白作为治疗靶点
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