School of Chemistry and Photon Science Institute, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Departamento de Química Inorgánica, Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, 46980, Valencia, Paterna, Spain.
Nat Commun. 2019 Aug 16;10(1):3720. doi: 10.1038/s41467-019-11635-6.
Molecules that are the size of small proteins are difficult to make. The most frequently examined route is via self-assembly, and one particular approach involves molecular nanocapsules, where ligands are designed that will enforce the formation of specific polyhedra of metals within the core of the structure. Here we show that this approach can be combined with mechanically interlocking molecules to produce nanocapsules that are decorated on their exterior. This could be a general route to very large molecules, and is exemplified here by the synthesis and structural characterization of a [13]rotaxane, containing 150 metal centres. Small angle X-ray scattering combined with atomistic molecular dynamics simulations demonstrate the compound is intact in solution.
小分子蛋白很难制造。最常被研究的方法是自组装，其中一种特殊的方法涉及分子纳米胶囊，其中设计了配体，以强制在结构核心内形成特定的金属多面体。在这里，我们表明这种方法可以与机械互锁分子结合使用，以产生在其外部进行装饰的纳米胶囊。这可能是一种制造非常大的分子的通用方法，这里通过合成和结构表征[13]轮烷来举例说明，其中包含 150 个金属中心。小角 X 射线散射与原子分子动力学模拟相结合证明，该化合物在溶液中是完整的。
