Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Cancer Lett. 2024 Nov 1;604:217273. doi: 10.1016/j.canlet.2024.217273. Epub 2024 Sep 19.
Circadian rhythms are 24-h rhythms governing temporal organization of behavior and physiology generated by molecular clocks composed of autoregulatory transcription-translation feedback loops (TTFLs). Disruption of circadian rhythms leads to a spectrum of pathologies, including cancer by triggering or being involved in different hallmarks. Clock control of phenotypic plasticity involved in tumorigenesis operates in aberrant dedifferentiating to progenitor-like cell states, generation of cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT) events. Circadian rhythms might act as candidates for regulatory mechanisms of cellular senescent and functional determinants of senescence-associated secretory phenotype (SASP). Reciprocal control between clock and epigenetics sheds light on post-transcriptional regulation of circadian rhythms and opens avenues for novel anti-cancer strategies. Additionally, disrupting circadian rhythms influences microbiota communities that could be associated with altered homeostasis contributing to cancer development. Herein, we summarize recent advances in support of the nexus between disruptions of circadian rhythms and cancer hallmarks of new dimensions, thus providing novel perspectives on potentially effective treatment approaches for cancer management.
昼夜节律是由分子钟组成的 24 小时节律，控制着行为和生理的时间组织，分子钟由自我调节的转录-翻译反馈环（TTFLs）组成。昼夜节律的破坏会导致一系列病理，包括癌症，通过触发或参与不同的特征而起作用。时钟控制肿瘤发生中的表型可塑性涉及异常去分化为祖细胞样细胞状态、癌症干细胞（CSCs）的产生和上皮-间充质转化（EMT）事件。昼夜节律可能是细胞衰老的调节机制和衰老相关分泌表型（SASP）的功能决定因素的候选者。时钟和表观遗传学之间的相互控制揭示了昼夜节律的转录后调控，并为新的抗癌策略开辟了途径。此外，破坏昼夜节律会影响微生物群落，这可能与改变的内稳态有关，从而促进癌症的发展。本文总结了支持昼夜节律破坏与癌症新维度特征之间关联的最新进展，从而为癌症管理的潜在有效治疗方法提供了新的视角。
