Jiangsu Key Laboratory of Marine Biotechnology, 59 Cangwu Road, Haizhou 222005, China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, 59 Cangwu Road, Haizhou 222005, China.
Int J Biol Macromol. 2019 Nov 1;140:98-101. doi: 10.1016/j.ijbiomac.2019.08.129. Epub 2019 Aug 15.
In this work, a water-soluble okra polysaccharide (OP-2) was prepared by hot water extraction, and the effects of OP-2 on the spermatogenesis of KKAy mice were investigated. Forty eight KKAy mice with similar initial body weights and lipid and blood glucose levels were randomly divided into four groups, i.e., one control group and three OP-2-treatment groups (treated with 50 mg/kg, 100 mg/kg and 150 mg/kg OP-2, respectively). Oral OP-2 administration increased high-density lipoprotein cholesterol, protein and superoxide dismutase levels in testis, sperm density, sperm movement and rate of normal morphology of KKAy mice and decreased serum total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose and insulin levels and nitrate oxide in testis of KKAy mice. The results indicated that OP-2 can effectively ameliorate the spermatogenesis of KKAy mice and may be used as an adjuvant drug for infertility with diabetes mellitus.
在这项工作中，通过热水提取制备了一种水溶性黄蜀葵多糖（OP-2），并研究了 OP-2 对 KKAy 小鼠生精的影响。48 只初始体重和血脂、血糖水平相似的 KKAy 小鼠被随机分为四组，即对照组和 3 个 OP-2 处理组（分别用 50mg/kg、100mg/kg 和 150mg/kg OP-2 处理）。口服 OP-2 给药增加了 KKAy 小鼠睾丸中高密度脂蛋白胆固醇、蛋白质和超氧化物歧化酶的水平，精子密度、精子运动和正常形态的比例，并降低了 KKAy 小鼠血清总胆固醇、低密度脂蛋白胆固醇、空腹血糖和胰岛素水平以及睾丸中的硝酸盐氧化物。结果表明，OP-2 可有效改善 KKAy 小鼠的生精功能，可作为糖尿病不育症的辅助药物。
