School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
Mol Nutr Food Res. 2013 Nov;57(11):2075-8. doi: 10.1002/mnfr.201300054. Epub 2013 Jul 26.
Okra is a tropical vegetable that is rich in polysaccharides. Here, we investigated the effects of okra polysaccharide (OP) on metabolic disorders in mice. We found that OP lowered body weight and glucose levels, improved glucose tolerance, and decreased serum total cholesterol levels in high-fat diet-fed C57BL/6 mice. OP regulated the gene expression of liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs) and their target genes in the liver and the adipose tissue of the mice. These results suggest that OP may have therapeutic effects on metabolic diseases via the inhibition of LXR and PPAR signaling.
黄秋葵是一种富含多糖的热带蔬菜。在这里，我们研究了黄秋葵多糖（OP）对高脂饮食喂养的 C57BL/6 小鼠代谢紊乱的影响。我们发现，OP 可降低体重和血糖水平，改善葡萄糖耐量，并降低血清总胆固醇水平。OP 调节了肝脏 X 受体（LXRs）和过氧化物酶体增殖物激活受体（PPARs）及其靶基因在小鼠肝脏和脂肪组织中的基因表达。这些结果表明，OP 通过抑制 LXR 和 PPAR 信号通路可能对代谢疾病具有治疗作用。
