Ignesti G, Buffoni F, Perretti M, Cintelli A
Dipartmento di Farmacologia Preclinica e Clinica M. Aiazzi Mancini, Firenze, Italy.
Agents Actions. 1988 Aug;25(1-2):43-7. doi: 10.1007/BF01969092.
In quail liver microsomes the metabolism of histamine is prevalently sustained by diaminoxidase (DAO). Treatment with phenobarbital (PB) and clofibrate (CF) does not modify DAO activity, while that with Aroclor 1254 (PCB) and beta-naphtoflavone (BNF) significantly decreases it. The decrease of DAO activity produced by these substances is not dependent on their direct inhibition of the enzyme. DAO decrease might represent a further possibility to discriminate among different inducers; moreover, it implies that histamine metabolism might be decreased, in quail liver, by some classes of inducers.
在鹌鹑肝脏微粒体中，组胺的代谢主要由二胺氧化酶（DAO）维持。用苯巴比妥（PB）和氯贝丁酯（CF）处理不会改变DAO活性，而用多氯联苯（Aroclor 1254，PCB）和β-萘黄酮（BNF）处理则会显著降低其活性。这些物质引起的DAO活性降低并不依赖于它们对该酶的直接抑制作用。DAO活性降低可能是区分不同诱导剂的另一种可能性；此外，这意味着在鹌鹑肝脏中，某些种类的诱导剂可能会降低组胺的代谢。
