Fu Qiang, Shaya Mahati, Li Shaoshan, Kugeluke Yalikun, Dilimulati Yisireyili, Liu Bo, Zhou Qingjiu
Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University (XJMU), Urumqi, Xinjiang 830011, P.R. China.
Department of Tumor Center, First Affiliated Hospital of Xinjiang Medical University (XJMU), Urumqi, Xinjiang 830011, P.R. China.
Oncol Lett. 2019 Aug;18(2):1344-1350. doi: 10.3892/ol.2019.10396. Epub 2019 May 23.
Macrophage capping protein (CAPG) genes were investigated based on The Cancer Genome Atlas (TCGA) database and clinical experiments. Glioblastoma (GBM) genes expression profiling chip of 529 disease samples and 10 normal samples selected from TCGA database were used for analysis, 25 brain glioma tissue samples and 15 normal brain tissues were collected in the Department of Neurosurgery of the First Affiliated Hospital of Xinjiang Medical University in China from 2016 to 2017 to analyze CAPG genes. TCGA results showed that the expression level of CAPG genes in GBM was higher than that in normal tissues, and the expression level of men, aged over 46 years and high grade gliomas in pathological stages was higher than that of women, aged ≤46 and low grade gliomas in pathological stages, and the survival time of high expression was shorter than that of low expression. The expression level of CAPG in glioma tissues was higher than that in normal tissues, and the expression level of CAPG in males was higher than that in females, as males had lymphatic transfer and low differentiation compared with females, but the expression level was not related to age. Survival analysis showed that higher expression level indicated shorter survival time, they were positively correlated. The expression of CAPG in glioma is high, and it is highly expressed with the severity of the disease, and it is also obviously related to the prognosis. Therefore, CAPG could be used as a biomarker for pathological grade and prognosis in glioma. However, the related studies are not consistent on the expression of different sex and ages, so further study is needed.
基于癌症基因组图谱（TCGA）数据库和临床实验对巨噬细胞帽蛋白（CAPG）基因进行了研究。使用从TCGA数据库中选取的529个疾病样本和10个正常样本的胶质母细胞瘤（GBM）基因表达谱芯片进行分析，2016年至2017年在中国新疆医科大学第一附属医院神经外科收集了25例脑胶质瘤组织样本和15例正常脑组织样本以分析CAPG基因。TCGA结果显示，GBM中CAPG基因的表达水平高于正常组织，年龄大于46岁的男性以及病理分期为高级别胶质瘤的CAPG基因表达水平高于年龄≤46岁的女性以及病理分期为低级别胶质瘤的，且高表达者的生存时间短于低表达者。胶质瘤组织中CAPG的表达水平高于正常组织，男性中CAPG的表达水平高于女性，因为男性与女性相比有淋巴转移且分化程度低，但表达水平与年龄无关。生存分析表明，表达水平越高表明生存时间越短，二者呈正相关。CAPG在胶质瘤中的表达较高，且随疾病严重程度而高表达，也与预后明显相关。因此，CAPG可作为胶质瘤病理分级和预后的生物标志物。然而，关于不同性别和年龄的表达相关研究结果并不一致，所以需要进一步研究。
