Hammami Muhammad B, Ohanisian Levonti, Kaur Navneet, Irshad Ahmad, Sidley Angel
Internal Medicine, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA.
Orthopaedic Surgery, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA.
Cureus. 2019 Jun 17;11(6):e4925. doi: 10.7759/cureus.4925.
Eosinophilic cholangitis (EC) is a rare benign disease characterized by transmural eosinophilic infiltration of the biliary tree that may result in biliary stricture and obstructive jaundice. The pathophysiology remains unknown but is theorized to involve an allergic mechanism. EC is diagnostically challenging as it may mimic cholangiocarcinoma (CCA) clinically and radiographically and involves a broad differential diagnosis including benign and malignant pathologies. In addition to tumor markers, ultrasonography, contrast-enhanced computed tomography (CT), and magnetic resonance cholangiopancreatography (MRCP), proper evaluation of malignant processes may need biopsy through endoscopic retrograde cholangiopancreatography (ERCP) and surgical exploration. We present the case of a 47-year-old female diagnosed with EC upon exploratory laparotomy.
嗜酸性胆管炎（EC）是一种罕见的良性疾病，其特征为胆管壁全层嗜酸性粒细胞浸润，可导致胆管狭窄和梗阻性黄疸。其病理生理机制尚不清楚，但理论上涉及过敏机制。EC的诊断具有挑战性，因为它在临床和影像学上可能酷似胆管癌（CCA），并且鉴别诊断范围广泛，包括良性和恶性病变。除了肿瘤标志物、超声、增强计算机断层扫描（CT）和磁共振胰胆管造影（MRCP）外，对恶性病变的正确评估可能需要通过内镜逆行胰胆管造影（ERCP）和手术探查进行活检。我们报告一例47岁女性患者，经剖腹探查术诊断为EC。
