Norrby S R, Jonsson M
Department of Infectious Diseases, University of Umeå, Sweden.
Antimicrob Agents Chemother. 1988 Aug;32(8):1278-81. doi: 10.1128/AAC.32.8.1278.
PD 127,391, a newly developed 4-quinolone chemically similar to ciprofloxacin, was studied in vitro by using agar and broth dilution and two inoculum sizes. PD 127,391 was found to be highly active against gram-negative aerobes, including Pseudomonas aeruginosa and other Pseudomonas spp. Its activity against gram-positive aerobes was better than that of ciprofloxacin.
PD 127,391是一种新开发的与环丙沙星化学结构相似的4-喹诺酮类药物，采用琼脂稀释法、肉汤稀释法以及两种接种量在体外进行了研究。结果发现，PD 127,391对包括铜绿假单胞菌和其他假单胞菌属在内的革兰氏阴性需氧菌具有高度活性。它对革兰氏阳性需氧菌的活性优于环丙沙星。
