新型喹诺酮类药物对棒状杆菌的体外活性比较
Comparative in vitro activities of new quinolones against coryneform bacteria.
作者信息
Martínez-Martínez L, Suárez A I, Ortega M C, Perea E J
机构信息
Department of Microbiology, University Hospital Virgen Macarena, University of Seville, Spain.
出版信息
Antimicrob Agents Chemother. 1994 Jun;38(6):1439-41. doi: 10.1128/AAC.38.6.1439.
The in vitro activities of eight quinolones against 115 coryneform bacteria (20 Corynebacterium jeikeium, 15 Corynebacterium minutissimum, 15 Corynebacterium striatum, 25 Corynebacterium urealyticum, 10 Corynebacterium xerosis, 10 Corynebacterium group ANF-1, 10 Corynebacterium group 12, and 10 Listeria monocytogenes) were determined. The MICs of ciprofloxacin, ofloxacin, and sparfloxacin for 90% of C. jeikeium, C. urealyticum, and C. xerosis isolates tested were > 16 micrograms/ml. Those of BAY Y 3118 and clinafloxacin against these species were 0.5 and 1 to 2 micrograms/ml, respectively. The MICs for 90% of all 115 strains tested were 0.5 microgram/ml for BAY Y 3118, 1 microgram/ml for clinafloxacin, 2 micrograms/ml for E-5068, 4 micrograms/ml for E-5065, and > 16 micrograms/ml for ciprofloxacin, ofloxacin, sparfloxacin, and E-4868.
测定了8种喹诺酮类药物对115株棒状杆菌（20株杰氏棒状杆菌、15株极小棒状杆菌、15株纹带棒状杆菌、25株解脲棒状杆菌、10株干燥棒状杆菌、10株ANF-1棒状杆菌群、10株12群棒状杆菌和10株单核细胞增生李斯特菌）的体外活性。环丙沙星、氧氟沙星和司帕沙星对90%受试的杰氏棒状杆菌、解脲棒状杆菌和干燥棒状杆菌分离株的最低抑菌浓度（MIC）>16微克/毫升。BAY Y 3118和克林沙星对这些菌种的MIC分别为0.5和1至2微克/毫升。对于所有115株受试菌株，90%的菌株对BAY Y 3118的MIC为0.5微克/毫升，对克林沙星为1微克/毫升，对E-5068为2微克/毫升，对E-5065为4微克/毫升，对环丙沙星、氧氟沙星、司帕沙星和E-4868则>16微克/毫升。
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