克林沙星对耐多药屎肠球菌的活性。
Activity of clinafloxacin against multidrug-resistant Enterococcus faecium.
作者信息
Burney S, Landman D, Quale J M
机构信息
Department of Medicine, Department of Veterans Affairs Medical Center, Brooklyn, New York 11209.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1668-70. doi: 10.1128/AAC.38.7.1668.
Abstract
Enterococci resistant to ampicillin, vancomycin, and/or aminoglycosides are a growing clinical problem. We studied the in vitro activity of the new fluoroquinolone clinafloxacin (PD 127,391) against 15 clinical isolates of multidrug-resistant Enterococcus faecium. In kill-kinetic studies, clinafloxacin (1 microgram/ml) was bactericidal against 7 of 12 susceptible isolates, although substantial regrowth occurred in 4 isolates at 48 h. The addition of ampicillin (20 micrograms/ml) resulted in bactericidal activity in all 12 isolates, and no regrowth was seen. For three isolates resistant to clinafloxacin, effective killing was not observed at these concentrations of antibiotics. Clinafloxacin with ampicillin shows promising activity against many of these multiply resistant enterococci.
摘要
对氨苄西林、万古霉素和/或氨基糖苷类耐药的肠球菌是一个日益严重的临床问题。我们研究了新型氟喹诺酮类药物克林沙星（PD 127,391）对15株耐多药屎肠球菌临床分离株的体外活性。在杀菌动力学研究中，克林沙星（1微克/毫升）对12株敏感分离株中的7株具有杀菌作用，尽管4株分离株在48小时时出现大量再生长。加入氨苄西林（20微克/毫升）后，所有12株分离株均有杀菌活性，且未见再生长。对于3株对克林沙星耐药的分离株，在这些抗生素浓度下未观察到有效杀灭作用。克林沙星与氨苄西林联合使用对许多这类多重耐药肠球菌显示出有前景的活性。
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