Ednie L M, Jacobs M R, Appelbaum P C
Department of Pathology, Hershey Medical Center, Pennsylvania 17033, USA.
Antimicrob Agents Chemother. 1998 May;42(5):1269-73. doi: 10.1128/AAC.42.5.1269.
Activities of clinafloxacin, ciprofloxacin, levofloxacin, sparfloxacin, trovafloxacin, piperacillin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, ceftazidime, and imipenem against 354 ciprofloxacin-susceptible and -intermediate-resistant organisms were tested by agar dilution. Clinafloxacin yielded the lowest quinolone MICs (< or = 0.5 microg/ml against ciprofloxacin-susceptible organisms and < or = 16.0 microg/ml against ciprofloxacin-intermediate-resistant organisms) compared to those of levofloxacin, trovafloxacin, and sparfloxacin. Ceftazidime, piperacillin alone or combined with tazobactam, trimethoprim-sulfamethoxazole, and imipenem usually yielded higher MICs against ciprofloxacin-resistant strains.
采用琼脂稀释法检测了克林沙星、环丙沙星、左氧氟沙星、司帕沙星、曲伐沙星、哌拉西林、哌拉西林 - 他唑巴坦、甲氧苄啶 - 磺胺甲恶唑、头孢他啶和亚胺培南对354株环丙沙星敏感及中介耐药菌的活性。与左氧氟沙星、曲伐沙星和司帕沙星相比，克林沙星产生的喹诺酮类最低抑菌浓度最低（对环丙沙星敏感菌≤0.5微克/毫升，对环丙沙星中介耐药菌≤16.0微克/毫升）。头孢他啶、单独使用的哌拉西林或与他唑巴坦联用、甲氧苄啶 - 磺胺甲恶唑和亚胺培南对环丙沙星耐药菌株通常产生较高的最低抑菌浓度。
