Emerg Infect Dis. 2019 Oct;25(10):1802-1809. doi: 10.3201/eid2510.190130. Epub 2019 Oct 17.
To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015-January 2016. We found confirmed infection for 19 (8 by reverse transcription PCR and 11 by serologic testing). Infection attack rates varied (2.7%-32.3%) by dormitory building. No deaths occurred. Independent risk factors for infection were direct contact with a confirmed case-patient and sharing a room with a confirmed case-patient; a protective factor was having an air conditioner in the bedroom. For 9 women from whom a second serum sample was collected, antibodies remained detectable at titers >1:20 by pseudoparticle neutralization tests (n = 8) and 90% plaque-reduction neutralization tests (n = 2). In closed high-contact settings, MERS coronavirus was highly infectious and pathogenicity was relatively low.
为了调查 2015 年 10 月沙特阿拉伯利雅得一家仅限女性居住的宿舍内发生的中东呼吸综合征（MERS）聚集性病例，我们于 2015 年 11 月至 2015 年 12 月和 2016 年 1 月期间收集了 828 名居民的流行病学信息、鼻咽/口咽拭子样本和血液样本。我们发现 19 人（8 人经逆转录 PCR 确诊，11 人经血清学检测确诊）感染了该病。不同宿舍楼的感染发病率不同（2.7%-32.3%）。未发生死亡病例。感染的独立危险因素为与确诊病例患者直接接触和与确诊病例患者同住一室；保护因素为卧室有空调。对 9 名采集了第二份血清样本的女性患者进行检测，用假病毒中和试验（n=8）和 90%蚀斑减少中和试验（n=2）检测，其抗体仍可检出效价>1:20。在密闭的高接触环境中，MERS 冠状病毒具有高度传染性，但其致病性相对较低。
