Okuyan Hamza Malik, Terzi Menderes Yusuf, Ozcan Oguzhan, Kalaci Aydiner
Department of Medical Services and Techniques, Hatay Vocational School of Health Services, Hatay Mustafa Kemal University, Hatay, Turkey.
Department of Medical Biology, Medical Faculty, Hatay Mustafa Kemal University, Hatay, Turkey.
Int J Rheum Dis. 2019 Oct;22(10):1884-1890. doi: 10.1111/1756-185X.13682. Epub 2019 Aug 19.
Osteoarthritis (OA) is one of the most common joint diseases causing physical disability in the aged population. OA pathogenesis is not fully known and yet there are no effective therapeutic options against OA. Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA) is a member of vitamin K-dependent protein family, and is involved in inflammation, cardiovascular diseases, cancer, and OA. In the present study, our aim was to detect serum and synovial fluid (SF) levels of UCMA and to analyze their correlation with radiographic findings and symptomatic severity in OA patients as well as the correlation between oxidative stress levels and SF UCMA levels.
Forty OA patients with cartilage degeneration and 20 patients with other knee joint disorders (non-OA control) were included in the present study. We used the Kellgren-Lawrence (KL) classification and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores to assess radiographic grading and symptomatic severity of OA, respectively. UCMA levels were measured in SF and serum. And also oxidative stress markers were analyzed in SF.
SF UCMA levels of OA patients were higher compared to those of the non-OA control group and were positively correlated with radiographic finding and symptomatic severity of OA. However, there was no significant correlation between oxidative markers of SF and the KL grade, WOMAC scores, and SF UCMA levels in OA patients.
There is a close connection between UCMA SF levels and symptomatic and radiographic severities of knee OA. Therefore, UCMA can be a promising biomarker in the diagnosis and/or prognosis of OA disease.
骨关节炎（OA）是导致老年人群身体残疾的最常见关节疾病之一。OA的发病机制尚未完全明确，且目前尚无有效的OA治疗方案。生长板上区与软骨基质相关蛋白（UCMA）是维生素K依赖蛋白家族的成员，与炎症、心血管疾病、癌症及OA有关。在本研究中，我们旨在检测OA患者血清和滑液（SF）中UCMA的水平，并分析其与OA患者影像学表现和症状严重程度的相关性，以及氧化应激水平与SF中UCMA水平的相关性。
本研究纳入了40例有软骨退变的OA患者和20例患有其他膝关节疾病的患者（非OA对照组）。我们分别使用Kellgren-Lawrence（KL）分级和西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分来评估OA的影像学分级和症状严重程度。检测SF和血清中的UCMA水平，并分析SF中的氧化应激标志物。
与非OA对照组相比，OA患者的SF中UCMA水平更高，且与OA的影像学表现和症状严重程度呈正相关。然而，OA患者SF中的氧化应激标志物与KL分级、WOMAC评分及SF中UCMA水平之间无显著相关性。
UCMA的SF水平与膝关节OA的症状和影像学严重程度密切相关。因此，UCMA有望成为OA疾病诊断和/或预后的生物标志物。
