Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Expert Opin Drug Discov. 2020 Apr;15(4):499-522. doi: 10.1080/17460441.2020.1722636. Epub 2020 Feb 6.
: The marine environment is a very promising resource for natural product research, with many of these reaching the market as new drugs, especially in the field of cancer therapy as well as the drug discovery pipeline for new antimicrobials. Exploitation for bioactive marine compounds with unique structures and novel bioactivity such as the isoquinoline alkaloid; trabectedin, the polyether macrolide; halichondrin B, and the peptide; dolastatin 10, requires the use of analytical techniques, which can generate unbiased, quantitative, and qualitative data to benefit the biodiscovery process. Metabolomics has shown to bridge this understanding and facilitate the development of new potential drugs from marine sources and particularly their microbial symbionts.: In this review, articles on applied secondary metabolomics ranging from 1990-2018 as well as to the last quarter of 2019 were probed to investigate the impact of metabolomics on drug discovery for new antibiotics and cancer treatment.: The current literature review highlighted the effectiveness of metabolomics in the study of targeting biologically active secondary metabolites from marine sources for optimized discovery of potential new natural products to be made accessible to a R&D pipeline.
海洋环境是一个极具前景的天然产物研究资源，其中许多已经作为新药进入市场，尤其是在癌症治疗领域以及新抗菌药物的药物发现管道中。开发具有独特结构和新颖生物活性的海洋生物活性化合物，如异喹啉生物碱； trabectedin、聚醚大环内酯； halichondrin B 和肽； dolastatin 10，需要使用分析技术，这些技术可以生成无偏、定量和定性的数据，从而有利于生物发现过程。代谢组学已经证明可以弥合这一理解差距，并促进从海洋来源特别是其微生物共生体中开发新的潜在药物。在这篇综述中，探讨了 1990 年至 2018 年以及 2019 年最后一个季度的应用二次代谢组学的文章，以调查代谢组学对新抗生素和癌症治疗药物发现的影响。目前的文献综述强调了代谢组学在研究海洋来源的具有生物活性的次生代谢产物方面的有效性，以优化发现潜在的新天然产物，使其能够进入研发管道。
